Del Fiacco M, Levanti M C, Dessi M L, Zucca G
Neuroscience. 1987 Apr;21(1):141-50. doi: 10.1016/0306-4522(87)90328-9.
The localization of substance P-like immunoreactive nervous structures in the human post-mortem hippocampal formation and parahippocampal gyrus was studied by the indirect immunofluorescence technique of Coons and Kaplan (1950), J. exp. Med. 91, 1-9. Specimens were obtained from brains of both newborn and adult subjects. Substance P-positive perikarya were easily detectable in these regions, being particularly abundant in the stratum oriens of the hippocampus and in the hilus of the fascia dentata. The nerve fibres and terminals were also widely and unevenly distributed. Comparison of the newborn and adult tissue revealed differences in the distribution of substance P-like immunoreactivity in ontogenetic stages. Our results, together with data available in the literature, further suggest that substance P is differently distributed in the various cortical areas of the human brain, and that the distribution of substance P may vary among species.
运用库恩斯和卡普兰（1950年，《实验医学杂志》91卷，第1 - 9页）的间接免疫荧光技术，对人类死后海马结构和海马旁回中P物质样免疫反应性神经结构进行了定位研究。标本取自新生儿和成人的大脑。在这些区域很容易检测到P物质阳性核周体，尤其在海马的原层和齿状回的门区大量存在。神经纤维和终末也广泛且不均匀地分布。新生儿和成人组织的比较揭示了在个体发育阶段P物质样免疫反应性分布的差异。我们的结果，连同文献中的现有数据，进一步表明P物质在人类大脑的不同皮质区域分布不同，并且P物质的分布可能因物种而异。
