Yu Wen, Ying Jun, Wang Xifeng, Liu Xing, Zhao Tiancheng, Yoon Sungtae, Zheng Qingcui, Fang Yang, Yang Danying, Hua Fuzhou
Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China.
Front Aging Neurosci. 2021 Jul 19;13:691230. doi: 10.3389/fnagi.2021.691230. eCollection 2021.
Neurodegenerative diseases are a class of slow-progressing terminal illnesses characterized by neuronal lesions, such as multiple sclerosis [MS, Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS)]. Their incidence increases with age, and the associated burden on families and society will become increasingly more prominent with aging of the general population. In recent years, there is growing studies have shown that lactosylceramide (LacCer) plays a crucial role in the progression of neurodegeneration, although these diseases have different pathogenic mechanisms and etiological characteristics. Based on latest research progress, this study expounds the pathogenic role of LacCer in driving central nervous system (CNS) inflammation, as well as the role of membrane microstructure domain (lipid rafts) and metabolite gangliosides, and discusses in detail their links with the pathogenesis of neurodegenerative diseases, with a view to providing new strategies and ideas for the study of pathological mechanisms and drug development for neurodegenerative diseases in the future.
神经退行性疾病是一类以神经元损伤为特征的进展缓慢的终末期疾病，如多发性硬化症（MS）、阿尔茨海默病（AD）、帕金森病（PD）和肌萎缩侧索硬化症（ALS）。它们的发病率随年龄增长而增加，随着总人口老龄化，相关的家庭和社会负担将变得越来越突出。近年来，越来越多的研究表明，乳糖神经酰胺（LacCer）在神经退行性变的进展中起关键作用，尽管这些疾病有不同的致病机制和病因特征。基于最新的研究进展，本研究阐述了LacCer在驱动中枢神经系统（CNS）炎症中的致病作用，以及膜微结构域（脂筏）和代谢产物神经节苷脂的作用，并详细讨论了它们与神经退行性疾病发病机制的联系，以期为未来神经退行性疾病的病理机制研究和药物开发提供新的策略和思路。
