Hahnemann Maria L, Nensa Felix, Kinner Sonja, Gerken Guido, Lauenstein Thomas C
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
J Magn Reson Imaging. 2015 Feb;41(2):354-60. doi: 10.1002/jmri.24557. Epub 2014 Jan 8.
To develop and implement an automated algorithm for visualizing and quantifying bowel motility using cine magnetic resonance imaging (MRI).
Four healthy volunteers as well as eight patients with suspected or diagnosed inflammatory bowel disease (IBD) underwent MR examinations on a 1.5T scanner. Coronal T2-weighted cine MR images were acquired in healthy volunteers without and with intravenous (i.v.) administration of butylscopolamine. In patients with IBD, cine MRI sequences were collected prior to standard bowel MRI. Bowel motility was assessed using an optical flow algorithm. The resulting motion vector magnitudes were presented as bowel motility maps. Motility changes after i.v. administration of butylscopolamine were measured in healthy volunteers. Inflamed bowel segments in patients were correlated with motility map findings.
The acquisition of bowel motility maps was feasible in all subjects examined. In healthy volunteers butylscopolamine led to quantitatively measurable decrease in bowel motility (mean decrease of 59%; P = 0.171). In patients with IBD, visualization of bowel movement by color-coded motility mapping allowed for the detection of segments with abnormal bowel motility. Inflamed bowel segments could be identified by exhibiting a decreased motility.
Our method is a feasible and promising approach for the assessment of bowel motility disorders.
开发并实施一种利用电影磁共振成像（MRI）可视化和量化肠道蠕动的自动化算法。
4名健康志愿者以及8名疑似或确诊为炎症性肠病（IBD）的患者在1.5T扫描仪上接受了磁共振检查。在健康志愿者中，分别在静脉注射丁溴东莨菪碱前后采集了冠状位T2加权电影磁共振图像。对于IBD患者，在标准肠道MRI检查之前采集电影MRI序列。使用光流算法评估肠道蠕动。所得的运动矢量大小以肠道蠕动图的形式呈现。在健康志愿者中测量静脉注射丁溴东莨菪碱后肠道蠕动的变化。将患者发炎的肠段与蠕动图结果进行关联分析。
在所检查的所有受试者中，获取肠道蠕动图都是可行的。在健康志愿者中，丁溴东莨菪碱导致肠道蠕动出现可定量测量的下降（平均下降59%；P = 0.171）。在IBD患者中，通过彩色编码的蠕动图可视化肠道运动能够检测到肠道蠕动异常的节段。发炎的肠段可通过蠕动减弱来识别。
我们的方法是评估肠道蠕动障碍的一种可行且有前景的方法。
