Centre for Medical Imaging, University College London, 3rd Floor East, 250 Euston Rd, London NW1 2PG, England; GI Physiology Unit, University College London Hospital, London, England.
Radiology. 2013 Nov;269(2):443-50. doi: 10.1148/radiology.13130151. Epub 2013 Jun 25.
To assess the repeatability in human volunteers of software-quantified small bowel motility captured with magnetic resonance (MR) imaging and to test the ability to detect changes in motility induced by pharmacologic agents.
The study was approved by the Royal Free Research Ethics Committee, and all subjects gave full written informed consent. Twenty-one healthy volunteers (14 men, seven women; mean age, 28 years) underwent cine MR imaging with a three-dimensional balanced turbo field-echo sequence to capture small bowel motility. Volume blocks (15 cm thick) were acquired every second during a 20-second breath hold. A randomized, blinded, placebo-controlled crossover study of either 0.5 mg neostigmine or saline (n = 11) or 20 mg intravenous butylscopolamine or saline (n = 10) was performed with motility MR imaging at baseline and repeated at a mean of 4 weeks (range, 2-7 weeks). Two readers independently drew regions of interest around the small bowel, and motility was quantified by using a registration algorithm that provided a global motility metric in arbitrary units. Repeatability of the motility measurements at baseline was assessed by using Bland-Altman and within-subject coefficient of variation measures. Changes in mean motility measurements after drug administration were compared with those after placebo administration by using paired t testing.
The repeatability between baseline measurements of motility was high; the Bland-Altman mean difference was -0.0025 (range, 0.28-0.4), the 95% limit of agreement was ±0.044 arbitrary units (au), and the within-subject coefficient of variation was 4.9%. Measured motility with neostigmine (mean, 0.39 au) was significantly higher than that with placebo (mean, 0.34 au; P < .001), whereas that with butylscopolamine (mean, 0.13 au) was significantly lower than that with placebo (mean, 0.30 au; P < .001).
Quantification of small bowel motility with use of MR imaging in healthy volunteers is repeatable and sensitive to changes induced by means of pharmacologic manipulation.
http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.13130151/-/DC1.
评估磁共振成像（MR）检测软件量化的人类志愿者小肠运动的重复性，并检验其检测药物诱导的运动变化的能力。
该研究经皇家自由研究伦理委员会批准，所有受试者均完全签署了书面知情同意书。21 名健康志愿者（14 名男性，7 名女性；平均年龄，28 岁）接受了三维平衡涡轮场回波序列的电影 MR 成像，以捕获小肠运动。在 20 秒屏气期间，每秒钟采集 15 cm 厚的容积块。采用随机、双盲、安慰剂对照交叉研究，对 11 名志愿者分别给予 0.5mg 新斯的明或生理盐水，对 10 名志愿者分别给予 20mg 静脉注射丁溴东莨菪碱或生理盐水，在基线时和平均 4 周（范围，2-7 周）后重复进行运动 MR 成像。两位观察者独立地在小肠周围画出感兴趣区，通过提供任意单位的全局运动度量的配准算法对运动进行量化。使用 Bland-Altman 和个体内变异系数测量来评估基线运动测量的重复性。通过配对 t 检验比较药物给药后的平均运动测量值与安慰剂给药后的变化。
基线运动测量的重复性高；Bland-Altman 平均差值为-0.0025（范围，0.28-0.4），95%一致性区间为±0.044 个任意单位（au），个体内变异系数为 4.9%。新斯的明（平均 0.39 au）组的运动幅度明显高于安慰剂（平均 0.34 au；P <.001），而丁溴东莨菪碱（平均 0.13 au）组的运动幅度明显低于安慰剂（平均 0.30 au；P <.001）。
磁共振成像检测软件量化的健康志愿者小肠运动具有可重复性，且对药物操作诱导的变化敏感。
http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.13130151/-/DC1.
