Inoue Akitoshi, Furukawa Akira, Yamamoto Hiroshi, Ohta Shinichi, Linh Nguyen Dai Hung, Syerikjan Tulyeubai, Kaida Sachiko, Yamaguchi Tsuyoshi, Murata Satoshi, Obata Toru, Tani Masaji, Murata Kiyoshi
Department of Radiology, Shiga University of Medical Science, Otsu, Shiga, Japan.
Department of Radiological Science, Tokyo Metropolitan University, Arakawa, Tokyo, Japan.
PLoS One. 2018 Jan 10;13(1):e0191044. doi: 10.1371/journal.pone.0191044. eCollection 2018.
Dai-kenchu-to (TJ-100) is an herbal medicine used to shorten the duration of intestinal transit by accelerating intestinal movement. However, intestinal movement in itself has not been evaluated in healthy volunteers using radiography, fluoroscopy, and radioisotopes because of exposure to ionizing radiation. The purpose of this study was to evaluate the effect of TJ-100 on intestinal motility using cinematic magnetic resonance imaging (cine MRI) with a steady-state free precession sequence. Ten healthy male volunteers received 5 g of either TJ-100 or lactose without disclosure of the identity of the substance. Each volunteer underwent two MRI examinations after taking the substances (TJ-100 and lactose) on separate days. They drank 1200 mL of tap water and underwent cine MRI after 10 min. A steady-state free precession sequence was used for imaging, which was performed thrice at 0, 10, 20, 30, 40, and 50 min. The bowel contraction frequency and distention score were assessed. Wilcoxon signed-rank test was used, and differences were considered significant at a P-value <0.05. The bowel contraction frequency tended to be greater in the TJ-100 group and was significantly different in the ileum at 20 (TJ-100, 8.95 ± 2.88; lactose, 4.80 ± 2.92; P < 0.05) and 50 min (TJ-100, 9.45 ± 4.49; lactose, 4.45 ± 2.65; P < 0.05) between the groups. No significant differences were observed in the bowel distention scores. Cine MRI demonstrated that TJ-100 activated intestinal motility without dependence on ileum distention.
大建中汤（TJ - 100）是一种草药制剂，通过加速肠道蠕动来缩短肠道运输时间。然而，由于存在电离辐射暴露风险，尚未在健康志愿者中使用X射线摄影、荧光镜检查和放射性同位素对肠道蠕动本身进行评估。本研究的目的是使用具有稳态自由进动序列的电影磁共振成像（cine MRI）来评估TJ - 100对肠道动力的影响。10名健康男性志愿者分别服用5克TJ - 100或乳糖，但未告知所服物质的身份。每位志愿者在不同日期服用这些物质（TJ - 100和乳糖）后接受两次MRI检查。他们饮用1200毫升自来水，10分钟后接受cine MRI检查。成像采用稳态自由进动序列，在0、10、20、30、40和50分钟时进行三次扫描。评估肠道收缩频率和扩张评分。采用Wilcoxon符号秩检验，P值<0.05时差异被认为具有统计学意义。TJ - 100组的肠道收缩频率有增加趋势，在回肠部位，两组在20分钟（TJ - 100，8.95±2.88；乳糖，4.80±2.92；P<0.05）和50分钟（TJ - 100，9.45±4.49；乳糖，4.45±2.65；P<0.05）时存在显著差异。肠道扩张评分未见显著差异。Cine MRI显示TJ - 100可激活肠道动力，且不依赖于回肠扩张。
