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主动脉瓣关闭不全合并主动脉根部瘤患者行主动脉瓣悬吊术的长期结果

Long-term results of aortic valve resuspension in patients with aortic valve insufficiency and aortic root aneurysm.

作者信息

Monsefi Nadejda, Zierer Andreas, Risteski Petar, Primbs Patrick, Miskovic Aleksandra, Karimian-Tabrizi Afsaneh, Folkmann Sandra, Moritz Anton

机构信息

Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany.

出版信息

Interact Cardiovasc Thorac Surg. 2014 Apr;18(4):432-7. doi: 10.1093/icvts/ivt530. Epub 2014 Jan 6.

Abstract

OBJECTIVES

'The David technique' may provide an alternative to conduit implantation in patients with an aneurysm of the ascending aorta and aortic valve insufficiency.

METHODS

From 1991 to 2013, the David technique was performed in 249 consecutive patients in our department. The patient mean age was 58 ± 14 years; 71 (29%) were female and 178 (71%) male. A modification of the David technique was performed by creating a pseudosinus in 43 patients (17%) and by creating a neosinus in 123 patients (49%). The mean follow-up was 6 ± 4.5 years.

RESULTS

There were six in-hospital (2.4%) and 30 late deaths (2.4%/patient-year). Cardiac-related events were the cause of death in three patients. The Kaplan-Meier estimate for 10 years survival was 77%. Four patients had perioperative neurological events, and only eight neurological events occurred during follow-up (0.6%/patient-year). Ten patients (0.8%/patient-year) required aortic valve replacement; one because of combined aortic valve stenosis and insufficiency and nine because of severe aortic valve insufficiency as a result of leaflet prolapse (n = 3), leaflet perforation (n = 1), abridgement of the right coronary leaflet (n = 1) and because of endocarditis (n = 4). Three cases of bleeding were observed (0.24%/patient-year). Freedom from reoperation or aortic valve insufficiency ≥2° was 80% at 10 years.

CONCLUSIONS

Aortic valve sparing to treat patients with an ascending aortic aneurysm with aortic valve insufficiency is a durable procedure. Aortic valve function remains stable for many years. Valve-related complications are rare, and the rate of reoperations is not increased in comparison to conduit root replacement.

摘要

目的

“大卫技术”可能为升主动脉瘤合并主动脉瓣关闭不全的患者提供一种替代人工血管植入的方法。

方法

1991年至2013年,我科连续对249例患者实施了大卫技术。患者平均年龄为58±14岁;女性71例(29%),男性178例(71%)。43例(17%)患者采用创建假窦的方式对大卫技术进行了改良,123例(49%)患者采用创建新窦的方式进行了改良。平均随访时间为6±4.5年。

结果

住院期间死亡6例(2.4%),晚期死亡30例(2.4%/患者年)。3例患者死于心脏相关事件。10年生存率的Kaplan-Meier估计值为77%。4例患者发生围手术期神经系统事件,随访期间仅发生8例神经系统事件(0.6%/患者年)。10例患者(0.8%/患者年)需要进行主动脉瓣置换;1例是因为合并主动脉瓣狭窄和关闭不全,9例是因为瓣叶脱垂(n = 3)、瓣叶穿孔(n = 1)、右冠状动脉瓣叶缩短(n = 1)以及心内膜炎(n = 4)导致的严重主动脉瓣关闭不全。观察到3例出血病例(0.24%/患者年)。10年时免于再次手术或主动脉瓣关闭不全≥2°的比例为80%。

结论

保留主动脉瓣治疗升主动脉瘤合并主动脉瓣关闭不全的患者是一种持久有效的手术方法。主动脉瓣功能多年来保持稳定。瓣膜相关并发症罕见,与人工血管根部置换相比,再次手术率并未增加。

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