Division of Gastroenterology, Hepatology and Nutrition, University of British Columbia , Vancouver, BC , Canada.
Division of Gastroenterology, Hepatology and Nutrition, University of British Columbia , Vancouver, BC , Canada ; Child and Family Research Institute, University of British Columbia , Vancouver, BC , Canada ; Department of Cellular and Physiological Sciences, BC Children's Hospital, University of British Columbia , Vancouver, BC , Canada.
Front Pediatr. 2013 Nov 6;1:34. doi: 10.3389/fped.2013.00034.
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gastrointestinal tract associated with significant morbidity. While IBD occurs in genetically susceptible individuals, the etiology is multifactorial, involving environmental influences, intestinal dysbiosis, and altered immune responses. The rising incidence of IBD in industrialized countries and the emergence of IBD in countries with traditionally low prevalence underscore the importance of environmental influences in the pathobiology of the disease. Moreover the high incidence of IBD observed in the South Asian immigrant population in the United Kingdom and Canada further supports the influence of environmental factors.
炎症性肠病（IBD）是一种慢性复发性胃肠道炎症性疾病，与显著的发病率有关。虽然 IBD 发生在遗传易感个体中，但病因是多因素的，涉及环境影响、肠道菌群失调和免疫反应改变。在工业化国家，IBD 的发病率不断上升，而在传统患病率较低的国家，IBD 的出现突显了环境影响在疾病发病机制中的重要性。此外，在英国和加拿大的南亚移民人群中观察到的 IBD 高发病率进一步支持了环境因素的影响。
