Department of Otolaryngology - Head and Neck Surgery, Wayne State University School of Medicine , Detroit, MI , USA.
Wayne State University School of Medicine , Detroit, MI , USA.
Front Pediatr. 2013 Dec 23;1:52. doi: 10.3389/fped.2013.00052.
Acute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this disease entity. The nasopharynx is a likely reservoir for infection with subsequent seeding of pathogens to the middle ear via planktonic shedding. Various modalities have been used to directly detect biofilm formation in the middle ear mucosa of children with AOM. Further insights into this disease may lead to new strategies for prevention and treatment.
急性中耳炎（AOM）是一种具有重大社会经济影响的多因素疾病。AOM 的发病机制归因于多种已确立的内部和外部因素。最近的证据强烈表明，细菌生物膜的形成是导致这种疾病的一个重要因素。鼻咽部可能是感染的储源，随后病原体通过浮游脱落播散到中耳。已经使用了各种方法来直接检测 AOM 患儿中耳黏膜中的生物膜形成。对这种疾病的进一步了解可能会导致新的预防和治疗策略。
