Müller-Bühl U, Diehm C, Krais T, Zimmermann R, Mörl H, Eckstein H H
Department of Internal Medicine, University of Heidelberg, Germany.
Eur J Clin Pharmacol. 1987;33(2):127-31. doi: 10.1007/BF00544555.
In a randomized patient-blind study iloprost or hydroxy-ethyl starch 200/0.5 were given i.v. 5 h daily for 2 weeks to 24 patients suffering from severe intermittent claudication due to peripheral vascular disease. An increase in pain-free walking distance of more than 50% occurred in 6 of 11 patients after the iloprost infusions and in 7 of 12 patients after HES treatment. No significant effects on haemodynamic or clinical chemistry tests were observed.
在一项随机患者盲法研究中,对24例因外周血管疾病导致严重间歇性跛行的患者静脉注射伊洛前列素或羟乙基淀粉200/0.5,每天5小时,持续2周。伊洛前列素输注后,11例患者中有6例无痛步行距离增加超过50%;羟乙基淀粉治疗后,12例患者中有7例无痛步行距离增加超过50%。未观察到对血流动力学或临床化学检测有显著影响。