J.L. Atkins, Department of Primary Care and Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK. Telephone: 020 7794 0500 Ext 34389. Fax: 0207 794 1224. E-mail:
J Nutr Health Aging. 2014 Jan;18(1):26-33. doi: 10.1007/s12603-013-0336-9.
To explore associations between low muscle mass and a wide range of lifestyle, dietary and cardiovascular risk factors in older men including metabolic risk factors, markers of inflammation, endothelial dysfunction and coagulation.
Cross-sectional study.
British Regional Heart Study.
4252 men aged 60-79 years.
PARTICIPANTS attended a physical examination in 1998-2000, and completed a general questionnaire and a food frequency questionnaire. Low muscle mass was assessed by two measures: midarm muscle circumference (MAMC) and fat-free mass index (FFMI). Associations between risk factors and low muscle mass were analysed using logistic regression.
Physical inactivity, insulin resistance, C-reactive protein, von Willebrand factor and fibrinogen were associated with significantly increased odds of low MAMC and FFMI after adjustment for body mass index, lifestyle characteristics and morbidity. Those with higher percent energy intake from carbohydrates showed decreased odds of low MAMC (OR: 0.73, 95% CI: 0.55-0.96) and FFMI (OR: 0.76, 95% CI: 0.58-0.99). Other dietary variables, smoking, alcohol intake, D-dimer, interleukin 6 and homocysteine showed no important associations with MAMC and FFMI.
Increasing physical activity, consuming a diet with a high proportion of energy from carbohydrates, and taking steps to prevent insulin resistance and reduce inflammation and endothelial dysfunction may help to reduce the risk of low muscle mass in older men.
探讨低肌肉质量与广泛的生活方式、饮食和心血管危险因素（包括代谢危险因素、炎症标志物、内皮功能障碍和凝血）在老年男性中的关联。
横断面研究。
英国区域心脏研究。
4252 名年龄在 60-79 岁的男性。
参与者于 1998-2000 年参加了体检，并完成了一般问卷和食物频率问卷。通过两种方法评估低肌肉质量：上臂中部肌肉周长（MAMC）和无脂肪质量指数（FFMI）。使用逻辑回归分析危险因素与低肌肉质量之间的关系。
体力活动不足、胰岛素抵抗、C 反应蛋白、血管性血友病因子和纤维蛋白原与低 MAMC 和 FFMI 的比值比显著增加相关，调整了体重指数、生活方式特征和发病率。碳水化合物能量摄入百分比较高的人，低 MAMC（OR：0.73，95%CI：0.55-0.96）和 FFMI（OR：0.76，95%CI：0.58-0.99）的几率降低。其他饮食变量、吸烟、饮酒、D-二聚体、白细胞介素 6 和同型半胱氨酸与 MAMC 和 FFMI 无重要关联。
增加体力活动、摄入高碳水化合物能量的饮食，并采取措施预防胰岛素抵抗以及降低炎症和内皮功能障碍，可能有助于降低老年男性低肌肉质量的风险。
