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艾沙康唑治疗播散性毛霉病患者。

Isavuconazole treatment of a patient with disseminated mucormycosis.

作者信息

Peixoto Driele, Gagne Lisa S, Hammond Sarah P, Gilmore Erin T, Joyce Amy C, Soiffer Robert J, Marty Francisco M

机构信息

Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

出版信息

J Clin Microbiol. 2014 Mar;52(3):1016-9. doi: 10.1128/JCM.03176-13. Epub 2014 Jan 8.

DOI:10.1128/JCM.03176-13
PMID:24403304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3957744/
Abstract

We report a patient with relapsed acute myelogenous leukemia after allogeneic stem cell transplantation who developed disseminated mucormycosis due to Rhizomucor pusillus/R. miehei involving lung, brain, and skin. After failing posaconazole and being intolerant to amphotericin, he was treated effectively with isavuconazole for over 6 months despite ongoing treatment for relapsed leukemia.

摘要

我们报告了1例异基因干细胞移植后复发的急性髓系白血病患者，其因米根霉/米黑根毛霉感染发生播散性毛霉病，累及肺、脑和皮肤。在泊沙康唑治疗失败且对两性霉素不耐受后，尽管其复发的白血病仍在持续治疗，但他接受了6个多月的艾沙康唑治疗，效果良好。

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本文引用的文献

1
Successful isavuconazole salvage therapy in a patient with invasive mucormycosis.侵袭性毛霉病患者成功接受艾沙康唑挽救治疗。
Infection. 2014 Apr;42(2):429-32. doi: 10.1007/s15010-013-0552-6. Epub 2013 Nov 12.
2
Evaluation of the pharmacokinetics and clinical utility of isavuconazole for treatment of invasive fungal infections.评估伊曲康唑治疗侵袭性真菌感染的药代动力学和临床实用性。
Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):759-65. doi: 10.1517/17425255.2012.683859. Epub 2012 Apr 25.
3
Mortality in hematologic malignancy and hematopoietic stem cell transplant patients with mucormycosis, 2001 to 2009.2001 年至 2009 年血液恶性肿瘤和造血干细胞移植患者中毛霉菌病的死亡率。
Antimicrob Agents Chemother. 2011 Nov;55(11):5018-21. doi: 10.1128/AAC.00536-11. Epub 2011 Aug 29.
4
Molecular methods to improve diagnosis and identification of mucormycosis.提高毛霉病诊断和鉴定的分子方法。
J Clin Microbiol. 2011 Jun;49(6):2151-3. doi: 10.1128/JCM.00256-11. Epub 2011 Apr 20.
5
Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole.新型三唑类抗真菌药物：聚焦于艾沙康唑、雷夫康唑和阿巴康唑。
Curr Opin Investig Drugs. 2010 Feb;11(2):165-74.
6
Limited penetration of posaconazole into cerebrospinal fluid in an allogeneic stem cell recipient with invasive pulmonary aspergillosis.泊沙康唑在一名患有侵袭性肺曲霉病的异基因干细胞受体的脑脊液中渗透有限。
Bone Marrow Transplant. 2009 Aug;44(4):269-70. doi: 10.1038/bmt.2009.17. Epub 2009 Feb 16.
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Antimicrob Agents Chemother. 2009 Jan;53(1):24-34. doi: 10.1128/AAC.00705-08. Epub 2008 Oct 27.
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Posaconazole concentrations in the central nervous system.泊沙康唑在中枢神经系统中的浓度。
J Antimicrob Chemother. 2008 Dec;62(6):1468-70. doi: 10.1093/jac/dkn409. Epub 2008 Sep 28.
9
In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species.艾沙康唑（BAL4815）、伏立康唑和氟康唑对1007株接合菌、念珠菌、曲霉菌、镰刀菌和赛多孢子菌属菌株的体外抗真菌活性。
Antimicrob Agents Chemother. 2008 Apr;52(4):1396-400. doi: 10.1128/AAC.01512-07. Epub 2008 Jan 22.
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New and emerging treatments for fungal infections.真菌感染的新型及新兴治疗方法。
J Antimicrob Chemother. 2008 Jan;61 Suppl 1:i19-30. doi: 10.1093/jac/dkm428.