Lerma E, Oliva E, Tugués D, Prat J
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain.
Virchows Arch. 1994;424(1):19-24. doi: 10.1007/BF00197388.
The clinicopathological and DNA flow cytometric data of 33 patients with stromal tumours of the gastrointestinal tract (STGIT) were analysed to select pathological features of prognostic value. Tumours had been previously classified as benign (21 cases) or malignant (12 cases). Data relating to poor prognosis statistically were local invasion, pathological grade, size greater than 10 cm, mitotic index (MI) and necrosis. Pathological grade was related to local invasion. Aneuploidy did not correlate with poor survival although a common trend was detected between both. DNA content may help to predict prognosis of STGIT, but its real value has not yet been clearly established. Currently, stage (invasion), size, MI and pathological grade remain the most useful prognostic factors.
分析33例胃肠道间质瘤（STGIT）患者的临床病理及DNA流式细胞术数据，以选择具有预后价值的病理特征。肿瘤先前已被分类为良性（21例）或恶性（12例）。与预后不良在统计学上相关的数据包括局部侵犯、病理分级、大小大于10 cm、有丝分裂指数（MI）和坏死。病理分级与局部侵犯有关。非整倍体与生存不良无相关性，尽管两者之间发现了一个共同趋势。DNA含量可能有助于预测STGIT的预后，但其实际价值尚未明确确立。目前，分期（侵犯情况）、大小、MI和病理分级仍然是最有用的预后因素。
