Abaya Tanya V F, Diwekar Mohit, Blair Steve, Tathireddy Prashant, Rieth Loren, Solzbacher Florian
University of Utah, Department of Electrical and Computer Engineering, 36 Wasatch Dr., Salt Lake City, Utah 84112.
University of Utah, Department of Electrical and Computer Engineering, 36 Wasatch Dr., Salt Lake City, Utah 84112bUniversity of Utah, Department of Bioengineering, 50 S Central Campus Dr., Salt Lake City, Utah 84112.
J Biomed Opt. 2014 Jan;19(1):15006. doi: 10.1117/1.JBO.19.1.015006.
We establish performance characteristics of needle-type waveguides in three-dimensional array architectures as light delivery interfaces into deep tissue for applications, such as optogenetic and infrared (IR) neural stimulation. A single optrode waveguide achieves as high as 90% transmission efficiency, even at tissue depths >1 mm. Throughout the visible and near-IR spectrum, the effective light attenuation through the waveguide is ∼3 orders of magnitude smaller than attenuation in tissue/water, as confirmed by both simulation and experimental results. Light emission profiles from the optrode tips into tissue were also measured. Beam widths of 70 to 150 μm and full-angle divergence ranging from 13 to 40 deg in tissue can be achieved. These beam characteristics satisfy a wide range of requirements for targeted illumination in neural stimulation.
我们建立了三维阵列结构中针型波导作为光传输界面进入深层组织的性能特征，用于光遗传学和红外（IR）神经刺激等应用。即使在组织深度>1毫米时，单个光电极波导也能实现高达90%的传输效率。在整个可见光和近红外光谱范围内，通过波导的有效光衰减比在组织/水中的衰减小约3个数量级，这一点通过模拟和实验结果均得到证实。还测量了从光电极尖端进入组织的发光轮廓。在组织中可以实现70至150μm的光束宽度和13至40度的全角发散。这些光束特性满足了神经刺激中靶向照明的广泛要求。
