Sadjadi Neda Seyed, Shahi Majid Mohammad, Jalali Mohammad-Taha, Haidari Fatemeh
1Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
J Diet Suppl. 2014 Mar;11(1):30-9. doi: 10.3109/19390211.2013.859214. Epub 2014 Jan 10.
This study examined the effects of caraway plant on blood levels of glucose, lipid profile, and C-reactive protein in diabetic rats.
Thirty two male Wistar rats were randomly divided into four groups: group 1: nondiabetic control rats, group 2: diabetic rats, group 3, and 4 (caraway treated diabetic groups): each rat was treated with caraway at doses of 1 g/kg in group 3 and 2 g/kg in group 4. Diabetes was induced by a single intraperitoneal injection of 60 mg/kg streptozotocin. Caraway was administered as aqueous extract orally once a day for 3 weeks. Finally, blood samples were collected and fasting blood glucose, serum lipid profile, and C-reactive protein levels were determined. Data were analyzed statistically by one-way Analysis of Variance and considered to be significant when p < .05.
Diabetic rats receiving 1 and 2 g/kg caraway extracts had significantly lower total cholesterol (p = .036 and p = .010, respectively), low-density lipoprotein (p = .001 and p = .002, respectively), non-HDL-C (p = .003 and p = .007, respectively), LDL-C to HDL-C ratio (p = .002) and atherogenic index (p = .001) than that of diabetic control rats. Moreover, there were significant changes in fasting blood glucose in diabetic groups treated with 1 and 2 g/kg caraway extracts (p = .001 and p = .027, respectively) compared with the diabetic control. However, caraway did not have any significant effect on C-reactive protein level in diabetic rats.
This study suggests that caraway can exhibit blood glucose and lipid lowering activities in diabetes, without any effect on C-reactive protein level.
本研究考察了香菜对糖尿病大鼠血糖水平、血脂谱及C反应蛋白的影响。
32只雄性Wistar大鼠随机分为四组：第1组：非糖尿病对照大鼠；第2组：糖尿病大鼠；第3组和第4组（香菜治疗糖尿病组）：第3组每只大鼠以1 g/kg的剂量给予香菜治疗，第4组每只大鼠以2 g/kg的剂量给予香菜治疗。通过单次腹腔注射60 mg/kg链脲佐菌素诱导糖尿病。香菜以水提取物的形式每天口服给药一次，持续3周。最后，采集血样并测定空腹血糖、血清血脂谱和C反应蛋白水平。数据采用单因素方差分析进行统计学分析，当p <.05时认为具有显著性差异。
接受1 g/kg和2 g/kg香菜提取物治疗的糖尿病大鼠的总胆固醇（分别为p =.036和p =.010）、低密度脂蛋白（分别为p =.001和p =.002）、非高密度脂蛋白胆固醇（分别为p =.003和p =.007）、低密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比值（p =.002）和动脉粥样硬化指数（p =.001）均显著低于糖尿病对照大鼠。此外，与糖尿病对照组相比，接受1 g/kg和2 g/kg香菜提取物治疗的糖尿病组空腹血糖有显著变化（分别为p =.001和p =.027）。然而，香菜对糖尿病大鼠的C反应蛋白水平没有任何显著影响。
本研究表明，香菜在糖尿病中可表现出血糖和血脂降低活性，而对C反应蛋白水平无影响。
