Department of Pharmacology, Faculty of Pharmacy, Annamalai University, Chidambaram, India; Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB), Department of Biology, University of Minho, Portugal.
Consorzio Mario Negri Sud, Department of Translational Pharmacology, Santa Maria Imbaro, Italy.
Chin J Nat Med. 2014 Feb;12(2):126-30. doi: 10.1016/S1875-5364(14)60020-0.
This study was aimed at evaluating the anti-diabetic activity of the ethanol and aqueous extracts of the leaf material of Barringtonia acutangula in a diabetic animal model.
The ethanolic and aqueous extracts (250 and 500 mg·kg(-1) body weight) of the leaves of B. acutangula were assessed for antidiabetic activity in a streptozotocin (STZ)-induced diabetes animal model following 21 days of treatment. Glibenclamide (0.6 mg·kg(-1) p.o.) was used as a positive control. The hematological parameters, such as blood glucose level, urea, creatinin, cholesterol, HDL-C, and LDL-C levels were examined.
An acute toxicity study (5 000 mg·kg(-1), p.o.) did not produce any symptoms of toxicity. Significant reductions in blood glucose level, and serum total cholesterol and triglyceride levels were noted in animals treated with the extract. The high density lipoprotein-cholesterol (HDLC) level was found to increase as compared with the diabetic control group.
These results suggest that the leaf aqueous and ethanolic extracts of B. acutangula have anti-diabetic effects. The aqueous extract of B. acutangula produced a similar effect when compared with the ethanol extract. It is proposed that consumption of B. acutangula in some form like tea may help the management of diabetes.
本研究旨在评估水黄皮叶的乙醇和水提取物在糖尿病动物模型中的抗糖尿病活性。
在 STZ 诱导的糖尿病动物模型中，用 21 天的时间评估了 B. acutangula 叶的乙醇和水提取物（250 和 500mg·kg(-1)体重）的抗糖尿病活性。格列本脲（0.6mg·kg(-1)po）用作阳性对照。检查了血液学参数，如血糖水平、尿素、肌酸酐、胆固醇、HDL-C 和 LDL-C 水平。
急性毒性研究（5000mg·kg(-1)，po）未产生任何毒性症状。与糖尿病对照组相比，用提取物治疗的动物的血糖水平以及血清总胆固醇和甘油三酯水平显著降低。与糖尿病对照组相比，高密度脂蛋白胆固醇（HDLC）水平升高。
这些结果表明，B. acutangula 的叶水提物和乙醇提取物具有抗糖尿病作用。与乙醇提取物相比，B. acutangula 的水提取物产生了类似的效果。有人提出，以茶等形式食用 B. acutangula 可能有助于糖尿病的管理。
