1 Department of Molecular Biology and Biochemistry, University of California , Irvine, Irvine, California.
DNA Cell Biol. 2014 Mar;33(3):122-7. doi: 10.1089/dna.2013.2304. Epub 2014 Jan 10.
All known positive sense single-stranded RNA viruses induce host cell membrane rearrangement for purposes of aiding viral genome replication and transcription. Members of the Nidovirales order are no exception, inducing intricate regions of double membrane vesicles and convoluted membranes crucial for the production of viral progeny. Although these structures have been well studied for some members of this order, much remains unclear regarding the biogenesis of these rearranged membranes. Here, we discuss what is known about these structures and their formation, compare some of the driving viral proteins behind this process across the nidovirus order, and examine possible routes of mechanism by which membrane rearrangement may occur.
所有已知的正链单链 RNA 病毒都会诱导宿主细胞膜重排，以辅助病毒基因组的复制和转录。套式病毒目（Nidovirales）的成员也不例外，它们会诱导双层膜泡和曲折膜的复杂区域，这对于产生病毒后代至关重要。尽管这些结构已经在该目中的一些成员中得到了很好的研究，但对于这些重排膜的生物发生过程，仍有许多不清楚的地方。在这里，我们讨论了这些结构及其形成的已知内容，比较了该病毒目中的一些驱动蛋白在这个过程中的作用，并研究了膜重排可能发生的机制途径。
