Cong Yingying, Verlhac Pauline, Reggiori Fulvio
Department of Cell Biology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Viruses. 2017 Jul 11;9(7):182. doi: 10.3390/v9070182.
Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numerous pathogens, including viruses, usurp autophagy in order to promote their propagation. are an order of enveloped viruses with large single-stranded positive RNA genomes. Four virus families (, , and ) are part of this order, which comprises several human and animal pathogens of medical and veterinary importance. In host cells, induce membrane rearrangements including autophagosome formation. The relevance and putative mechanism of autophagy usurpation, however, remain largely elusive. Here, we review the current knowledge about the possible interplay between and autophagy.
自噬是一种保守的细胞内分解代谢途径，它使细胞能够通过称为自噬体的特殊双膜囊泡降解有害成分来维持体内平衡。在过去几十年中，已发现包括病毒在内的众多病原体利用自噬来促进其繁殖。 是一类具有大的单链正RNA基因组的包膜病毒目。四个病毒科（ 、 、 和 ）属于这个目，其中包括几种具有医学和兽医学重要性的人类和动物病原体。在宿主细胞中， 诱导包括自噬体形成在内的膜重排。然而，自噬被利用的相关性和推定机制在很大程度上仍然难以捉摸。在这里，我们综述了关于 与自噬之间可能相互作用的当前知识。
