Mazumder Debendra Nath Guha, Deb Debasree, Biswas Anirban, Saha Chandan, Nandy Ashoke, Das Arabinda, Ghose Aloke, Bhattacharya Kallol, Mazumdar Kunal Kanti
a DNGM Research Foundation , Kolkata , India.
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2014;49(5):555-64. doi: 10.1080/10934529.2014.859042.
The authors investigated association of arsenic intake through water and diet and arsenic level in urine in people living in arsenic endemic region in West Bengal supplied with arsenic-safe water (<50 μg L(-1)). Out of 94 (Group-1A) study participants using water with arsenic level <50 μg L(-1), 72 participants (Group-1B) were taking water with arsenic level <10 μg L(-1). Multiple regressions analysis conducted on the Group-1A participants showed that daily arsenic dose from water and diet were found to be significantly positively associated with urinary arsenic level. However, daily arsenic dose from diet was found to be significantly positively associated with urinary arsenic level in Group-1B participants only, but no significant association was found with arsenic dose from water in this group. In a separate analysis, out of 68 participants with arsenic exposure through diet only, urinary arsenic concentration was found to correlate positively (r = 0.573) with dietary arsenic in 45 participants with skin lesion while this correlation was insignificant (r = 0.007) in 23 participants without skin lesion. Our study suggested that dietary arsenic intake was a potential pathway of arsenic exposure even where arsenic intake through water was reduced significantly in arsenic endemic region in West Bengal. Observation of variation in urinary arsenic excretion in arsenic-exposed subjects with and without skin lesion needed further study.
作者调查了西孟加拉邦砷病区居民通过饮水和饮食摄入砷与尿砷水平之间的关联，这些居民供应的是砷安全水（<50 μg L⁻¹）。在94名（1A组）使用砷含量<50 μg L⁻¹水的研究参与者中，72名参与者（1B组）饮用的水砷含量<10 μg L⁻¹。对1A组参与者进行的多元回归分析表明，来自水和饮食的每日砷剂量与尿砷水平显著正相关。然而，仅在1B组参与者中发现饮食中的每日砷剂量与尿砷水平显著正相关，而该组中未发现与饮水砷剂量有显著关联。在另一项分析中，在仅通过饮食接触砷的68名参与者中发现，45名有皮肤病变的参与者尿砷浓度与饮食砷呈正相关（r = 0.573），而23名无皮肤病变的参与者中这种相关性不显著（r = 0.007）。我们的研究表明，即使在西孟加拉邦砷病区通过饮水摄入的砷显著减少的情况下，饮食中砷的摄入仍是砷暴露的一个潜在途径。对有和无皮肤病变的砷暴露受试者尿砷排泄变化的观察需要进一步研究。
