Department of Health Systems and Services, Pan American Health Organization (PAHO), 525 23rd St NW, Washington, DC 20037, USA.
Department of Health Systems and Services, Pan American Health Organization (PAHO), 525 23rd St NW, Washington, DC 20037, USA.
J Clin Epidemiol. 2014 Mar;67(3):314-24. doi: 10.1016/j.jclinepi.2013.10.007. Epub 2014 Jan 8.
The aim of this study was to identify and prioritize research gaps to help decrease maternal mortality.
We conducted a two-stage survey. We provided participants (Cochrane Collaboration experts) with a list of 319 problem/population, intervention, comparison, and outcome questions built from 178 Cochrane systematic reviews. Questions were classified according to causes of maternal death. Respondents of the first round refined the research questions and prioritized them by eliminating those that were considered of low priority, according to four criteria. They also included additional questions. In the second round, respondents prioritized 62 questions.
The overall response rates for the first and second rounds were 47% (73 of 155) and 17% (363 of 2,121), respectively. Participants ranked 62 of the research questions as "very relevant." Approximately 20% of all questions that were identified in Cochrane reviews and two-third of questions of the second round were considered of "very high priority." More women (235) than men (128) participated in the survey. We did not find statistically significant differences when comparing the groups of very relevant questions by the type of respondent, income, country, and round.
We identified research priorities by mapping and improving the understanding of research needs in low- and middle-income settings internationally.
本研究旨在确定并优先考虑研究空白，以帮助降低孕产妇死亡率。
我们进行了两阶段调查。我们向参与者（Cochrane 协作组织专家）提供了一份由 178 项 Cochrane 系统评价构建的 319 个问题/人群、干预、比较和结局问题清单。问题根据孕产妇死亡的原因进行分类。第一轮的回复者根据四项标准，对研究问题进行了精炼并根据优先级进行了排序，淘汰了那些被认为优先级较低的问题。他们还增加了一些其他问题。在第二轮中，回复者对 62 个问题进行了优先级排序。
第一轮和第二轮的总体回复率分别为 47%（73/155）和 17%（363/2,121）。参与者将 62 个研究问题评为“非常相关”。大约 20%的 Cochrane 综述中确定的所有问题和第二轮问题的三分之二被认为具有“非常高的优先级”。参与调查的女性（235 人）多于男性（128 人）。我们没有发现按回复者类型、收入、国家和轮次对非常相关问题组进行比较时存在统计学上的显著差异。
我们通过映射和提高对国际上中低收入国家研究需求的理解，确定了研究重点。
