School of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China.
J Biomater Sci Polym Ed. 2013;24(11):1378-90. doi: 10.1080/09205063.2012.762292. Epub 2013 Jan 21.
An ideal material for maxillofacial prostheses has not been found. We created a novel material: silicone elastomer filled with hollow microspheres and characterized its biomechanical properties. Expancel hollow microspheres were mixed with MDX4-4210 silicone elastomer using Q7-9180 silicone fluid as diluent. The volume fractions of microspheres were 0, 5, 15, and 30% v/v (volume ratio to the total volume of MDX4-4210 and microspheres). The microspheres dispersed well in the matrix. The physical properties and biocompatibility of the composites were examined. Shock absorption was the greatest by the 5% v/v composite, and decreased with increasing concentrations of microspheres. The density, thermal conductivity, Shore A hardness, tear and tensile strength decreased with increasing concentrations of microspheres, while elongation at break increased. Importantly, the tear strength of all composites was markedly lower than that of pure silicone elastomer. Cell viability assays indicated that the composite was of good biocompatibility. The composite with a volume fraction of 5% exhibited the optimal properties for use as a maxillofacial prosthesis, though its tear strength was markedly lower than that of silicone elastomer. In conclusion, we developed a novel light and soft material with good flexibility and biocompatibility, which holds a promising prospect for clinical application as maxillofacial prosthesis.
尚未找到理想的颌面赝复体材料。我们研制了一种新型材料：中空微球填充硅橡胶弹性体，并对其生物力学性能进行了表征。将 Expancel 中空微球与 MDX4-4210 硅橡胶弹性体混合，并用 Q7-9180 硅酮流体作为稀释剂。微球的体积分数分别为 0、5、15 和 30%v/v（相对于 MDX4-4210 和微球的总体积比）。微球在基质中分散良好。研究了复合材料的物理性能和生物相容性。5%v/v 复合材料的减震性能最好，随着微球浓度的增加而降低。密度、导热系数、邵氏 A 硬度、撕裂强度和拉伸强度随微球浓度的增加而降低，而断裂伸长率增加。重要的是，所有复合材料的撕裂强度明显低于纯硅橡胶弹性体。细胞活力测定表明该复合材料具有良好的生物相容性。体积分数为 5%的复合材料具有最佳的颌面赝复体性能，尽管其撕裂强度明显低于硅橡胶弹性体。总之，我们开发了一种新型的轻质柔软材料，具有良好的柔韧性和生物相容性，有望作为颌面赝复体在临床上得到应用。
