文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

微小RNA-34a通过靶向KLF4基因调控肝细胞凋亡。

MiR-34a regulates apoptosis in liver cells by targeting the KLF4 gene.

作者信息

Chen Qiu, Li Lei, Tu Yu, Zheng Lu Lin, Liu Wei, Zuo Xue Yong, He Yong Ming, Zhang Shu Yu, Zhu Wei, Cao Jian Ping, Cui Feng Mei, Hou Jun

机构信息

Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China.

出版信息

Cell Mol Biol Lett. 2014 Mar;19(1):52-64. doi: 10.2478/s11658-013-0115-y. Epub 2014 Jan 10.

DOI:10.2478/s11658-013-0115-y
PMID:24415058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6275989/
Abstract

MicroRNAs (miRNAs) regulate gene expression by inhibiting translation or targeting messenger RNA (mRNA) for degradation in a posttranscriptional fashion. In this study, we show that ectopic expression of miR-34a-5p reduces the mRNA and protein levels of Krüppel-like factor 4 (KLF4). We also demonstrate that miR-34a targets the 3'-untranslated mRNA region of KLF4 and show that overexpression of miR-34a induces a significant level of apoptosis in BNL CL.2 cells exposed to doxorubicin or 10 Gy X-ray. Our data suggest that the effects of miR-34a on apoptosis occur due to the downregulation of KLF4.

摘要

微小RNA（miRNA）通过抑制翻译或靶向信使核糖核酸（mRNA）以转录后方式进行降解来调控基因表达。在本研究中，我们发现异位表达的miR-34a-5p可降低Krüppel样因子4（KLF4）的mRNA和蛋白质水平。我们还证明miR-34a靶向KLF4的3'非翻译mRNA区域，并表明miR-34a的过表达在暴露于阿霉素或10 Gy X射线的BNL CL.2细胞中诱导显著水平的细胞凋亡。我们的数据表明，miR-34a对细胞凋亡的影响是由于KLF4的下调所致。

相似文献

[1]
MiR-34a regulates apoptosis in liver cells by targeting the KLF4 gene.

Cell Mol Biol Lett. 2014-3

[2]
Downregulation of miR-34a ameliorates inflammatory response and apoptosis induced by renal ischemia-reperfusion by promoting Kruppel-like factor 4 expression.

Eur Rev Med Pharmacol Sci. 2020-11

[3]
Kruppel-like factor 4 regulates keratinocyte senescence.

Biochem Biophys Res Commun. 2018-3-26

[4]
Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest.

FEBS Lett. 2008-4-30

[5]
Immune checkpoint inhibitor induces cardiac injury through polarizing macrophages via modulating microRNA-34a/Kruppel-like factor 4 signaling.

Cell Death Dis. 2020-7-24

[6]
Inhibition of miRNA-34a Promotes M2 Macrophage Polarization and Improves LPS-Induced Lung Injury by Targeting Klf4.

Genes (Basel). 2020-8-20

[7]
MicroRNA-34a inhibits the proliferation and promotes the apoptosis of non-small cell lung cancer H1299 cell line by targeting TGFβR2.

Tumour Biol. 2015-4

[8]
Baihui (DU20)-penetrating-Qubin (GB7) acupuncture regulates microglia polarization through miR-34a-5p/Klf4 signaling in intracerebral hemorrhage rats.

Exp Anim. 2021-11-10

[9]
miR-335 directly, while miR-34a indirectly modulate survivin expression and regulate growth, apoptosis, and invasion of gastric cancer cells.

Tumour Biol. 2016-2

[10]
c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver.

Mol Cell Biol. 2014-1-13

引用本文的文献

[1]
CORM-A1 Alleviates Pro-Atherogenic Manifestations via miR-34a-5p Downregulation and an Improved Mitochondrial Function.

Antioxidants (Basel). 2023-4-25

[2]
Involvement of miRNA-34a regulated Krüppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells.

Respir Res. 2022-12-10

[3]
Radiation-induced liver disease: beyond DNA damage.

Cell Cycle. 2023-3

[4]
Puerarin Reduces Radiation-Induced Vascular Endothelial Cell Damage Via miR-34a/Placental Growth Factor.

Dose Response. 2022-1-19

[5]
Targeting microRNAs with thymoquinone: a new approach for cancer therapy.

Cell Mol Biol Lett. 2021-10-9

[6]
Radiation-induced liver injury and hepatocyte senescence.

Cell Death Discov. 2021-9-16

[7]
Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics.

Gut Microbes. 2021

[8]
From Liver Cirrhosis to Cancer: The Role of Micro-RNAs in Hepatocarcinogenesis.

Int J Mol Sci. 2021-2-2

[9]
MicroRNA regulation of cholesterol metabolism.

Ann N Y Acad Sci. 2021-7

[10]
Endothelial dysfunction in neuroprogressive disorders-causes and suggested treatments.

BMC Med. 2020-10-19

本文引用的文献

[1]
MicroRNAs in the ionizing radiation response and in radiotherapy.

Curr Opin Genet Dev. 2013-2-28

[2]
MicroRNAs in human cancer.

Adv Exp Med Biol. 2013

[3]
MicroRNA-34a promotes cardiomyocyte apoptosis post myocardial infarction through down-regulating aldehyde dehydrogenase 2.

Curr Pharm Des. 2013

[4]
Analysis of p53 and miRNA expression after irradiation of glioblastoma cell lines.

Anticancer Res. 2012-11

[5]
Genistein inhibits cell growth and induces apoptosis through up-regulation of miR-34a in pancreatic cancer cells.

Curr Drug Targets. 2012-12

[6]
Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cells.

Int J Cancer. 2012-6-26

[7]
p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

PLoS Biol. 2012-2-28

[8]
MicroRNA functions in stress responses.

Mol Cell. 2010-10-22

[9]
MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cells.

Mol Pharmacol. 2010-3-18

[10]
Targeting of mRNAs by multiple miRNAs: the next step.

Oncogene. 2010-3-1

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索