螺旋断层放疗治疗前列腺癌患者的照射时间的经验估计。
Empirical estimation of beam-on time for prostate cancer patients treated on Tomotherapy.
作者信息
Skórska Małgorzata, Piotrowski Tomasz
机构信息
Department of Medical Physics, Greater Poland Cancer Centre, Poznan, Poland.
Department of Medical Physics, Greater Poland Cancer Centre, Poznan, Poland ; Department of Electroradiology, University of Medical Sciences, Poznan, Poland.
出版信息
Rep Pract Oncol Radiother. 2013 Feb 4;18(4):201-8. doi: 10.1016/j.rpor.2012.12.005. eCollection 2013.
BACKGROUND AND AIM
This study proposed a method to estimate the beam-on time for prostate cancer patients treated on Tomotherapy when FW (field width), PF (pitch factor), modulation factor (MF) and treatment length (TL) were given.
MATERIAL AND METHODS
THE STUDY WAS DIVIDED INTO TWO PARTS: building and verifying the model. To build a model, 160 treatment plans were created for 10 patients. The plans differed in combination of FW, PF and MF. For all plans a graph of beam-on time as a function of TL was created and a linear trend function was fitted. Equation for each trend line was determined and used in a correlation model. Finally, 62 plans verified the treatment time computation model - the real execution time was compared with our estimation and irradiation time calculated based on the equation provided by the manufacturer.
RESULTS
A linear trend function was drawn and the coefficient of determination R (2) and the Pearson correlation coefficient r were calculated for each of the 8 trend lines corresponding to the adequate treatment plan. An equation to correct the model was determined to estimate more accurately the beam-on time for different MFs. From 62 verification treatment plans, only 5 disagreed by more than 60 s with the real time from the HT software. Whereas, for the equation provided by the manufacturer the discrepancy was observed in 16 cases.
CONCLUSIONS
Our study showed that the model can well predict the treatment time for a given TL, MF, FW and it can be used in clinical practice.
背景与目的
本研究提出了一种在已知射野宽度（FW）、螺距因子（PF）、调制因子（MF）和治疗长度（TL）的情况下，估算接受螺旋断层放疗的前列腺癌患者照射时间的方法。
材料与方法
本研究分为两部分：构建并验证模型。为构建模型，为10例患者创建了160个治疗计划。这些计划在FW、PF和MF的组合上有所不同。针对所有计划，绘制了照射时间随TL变化的图表，并拟合了线性趋势函数。确定了每条趋势线的方程，并将其用于相关模型。最后，62个计划对治疗时间计算模型进行了验证——将实际执行时间与我们的估算值以及根据制造商提供的公式计算出的照射时间进行了比较。
结果
绘制了线性趋势函数，并针对与合适治疗计划相对应的8条趋势线中的每一条计算了决定系数R²和皮尔逊相关系数r。确定了一个校正模型的方程，以更准确地估算不同MF下的照射时间。在62个验证治疗计划中，只有5个与螺旋断层放疗软件的实际时间相差超过60秒。而对于制造商提供的公式，有16例出现差异。
结论
我们的研究表明，该模型能够很好地预测给定TL、MF、FW时的治疗时间，可用于临床实践。
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