Arnould J M
Arch Int Physiol Biochim. 1987 Mar;95(1):43-55. doi: 10.3109/13813458709075024.
The central nervous system of Carcinus maenas synthesizes radioactive histamine when incubated in the presence of [14C] histidine and pyridoxal-5' phosphate. This biosynthesis increases linearly as a function of the amount of enzyme and the incubation time. It is not effected by heart, muscle or hepatopancreas extracts nor by haemolymph. Thus histamine appears to be synthesized mainly in the nervous system. The latter is also the seat of carcinine (beta-alanylhistamine) biosynthesis. Since carcinine seems to be a product of histamine neutralization, histamine metabolism should take place in its entirety in the nervous system. Thus histamine appears to be implicated in the neuronal activity of Carcinus. Different areas of the crustacean central nervous system: brain, eyestalks and thoracic ganglionic mass biosynthesize and metabolize histamine. Thus they all could contain sites of action for histamine. The nervous systems of two other Decapodes, Cancer and Astacus also effect histamine biosynthesis but don't metabolize it into carcinine.
当在[14C]组氨酸和磷酸吡哆醛-5′-磷酸存在的条件下孵育时，滨蟹的中枢神经系统会合成放射性组胺。这种生物合成作为酶量和孵育时间的函数呈线性增加。它不受心脏、肌肉或肝胰腺提取物以及血淋巴的影响。因此，组胺似乎主要在神经系统中合成。神经系统也是甜菜碱（β-丙氨酰组胺）生物合成的场所。由于甜菜碱似乎是组胺中和的产物，组胺代谢应该在神经系统中完整地进行。因此，组胺似乎与滨蟹的神经元活动有关。甲壳类动物中枢神经系统的不同区域：脑、眼柄和胸神经节团块会生物合成和代谢组胺。因此它们都可能含有组胺的作用位点。另外两种十足目动物——黄道蟹和螯虾的神经系统也会影响组胺的生物合成，但不会将其代谢为甜菜碱。
