Classification plays a critical role in false positive reduction (FPR) in lung nodule computer aided detection (CAD). The difficulty of FPR lies in the variation of the appearances of the nodules, and the imbalance distribution between the nodule and non-nodule class. Moreover, the presence of inherent complex structures in data distribution, such as within-class imbalance and high-dimensionality are other critical factors of decreasing classification performance. To solve these challenges, we proposed a hybrid probabilistic sampling combined with diverse random subspace ensemble. Experimental results demonstrate the effectiveness of the proposed method in terms of geometric mean (G-mean) and area under the ROC curve (AUC) compared with commonly used methods.