Murakami Kentaro, Sasaki Satoshi, Uenishi Kazuhiro
Northern Ireland Centre for Food and Health (NICHE), University of Ulster, Coleraine, United Kingdom; JSPS Postdoctoral Fellow for Research Abroad, Japan Society for the Promotion of Science (JSPS), Tokyo, Japan; Department of Social and Preventive Epidemiology, School of Public Health, University of Tokyo, Tokyo, Japan.
Department of Social and Preventive Epidemiology, School of Public Health, University of Tokyo, Tokyo, Japan.
Nutr Res. 2014 Jan;34(1):25-30. doi: 10.1016/j.nutres.2013.09.004. Epub 2013 Oct 26.
It has been suggested that diets which enhance diurnal insulin secretion, such as a high glycemic index (GI) and glycemic load (GL) diet, can be expected to increase homocysteine levels. We investigated the hypothesis that dietary GI and GL are positively associated with serum homocysteine concentration in a group of free-living young Japanese women. This preliminary cross-sectional study included 1050 female Japanese dietetic students aged 18 to 22 years. Dietary intake was assessed using a validated, self-administered, comprehensive diet history questionnaire. Fasting blood samples were collected and serum homocysteine concentrations were measured. Adjustment was made for survey year, region, municipality level, current smoking, current alcohol consumption, dietary supplement use, physical activity, body mass index, energy intake, and intakes of B vitamins (folate, vitamin B6, vitamin B12, and riboflavin). After adjustment for nondietary confounding factors, both dietary GI and GL were positively associated with homocysteine concentration (both P for trend=.001). The positive association between dietary GI and homocysteine concentration remained after further adjustment for intakes of B vitamins. Mean (95% confidence interval) values of serum homocysteine concentration for each quintile of dietary GI were 6.9 (6.7-7.2), 7.1 (6.8-7.3), 7.0 (6.7-7.2), 7.4 (7.2-7.7), and 7.3 (7.0-7.6) μmol/L, respectively (P for trend = .04). Conversely, there was no association between dietary GL and homocysteine concentration after further adjustment for intakes of B vitamins (P for trend = .40). To conclude, in a group of free-living young Japanese women, dietary GI, but not GL, was independently and positively associated with serum homocysteine concentration.
有人提出，那些能增强日间胰岛素分泌的饮食，比如高血糖指数（GI）和血糖负荷（GL）饮食，可能会使同型半胱氨酸水平升高。我们调查了这样一个假设：在一群生活自由的年轻日本女性中，饮食GI和GL与血清同型半胱氨酸浓度呈正相关。这项初步的横断面研究纳入了1050名年龄在18至22岁的日本女性营养学专业学生。通过一份经验证的、自行填写的、全面的饮食史问卷来评估饮食摄入量。采集空腹血样并测量血清同型半胱氨酸浓度。对调查年份、地区、城市级别、当前吸烟情况、当前饮酒情况、膳食补充剂使用情况、身体活动、体重指数、能量摄入以及B族维生素（叶酸、维生素B6、维生素B12和核黄素）的摄入量进行了校正。在校正非饮食混杂因素后，饮食GI和GL均与同型半胱氨酸浓度呈正相关（趋势P值均为 = 0.001）。在进一步校正B族维生素摄入量后，饮食GI与同型半胱氨酸浓度之间的正相关关系依然存在。饮食GI每五分位数的血清同型半胱氨酸浓度的均值（95%置信区间）分别为6.9（6.7 - 7.2）、7.1（6.8 - 7.3）、7.0（6.7 - 7.2）、7.4（7.2 - 7.7）和7.3（7.0 - 7.6）μmol/L（趋势P值 = 0.04）。相反，在进一步校正B族维生素摄入量后，饮食GL与同型半胱氨酸浓度之间没有关联（趋势P值 = 0.40）。总之，在一群生活自由的年轻日本女性中，饮食GI而非GL与血清同型半胱氨酸浓度独立且呈正相关。
