白细胞介素-22：治疗自身免疫性疾病的可能靶点。
Interleukin-22: a likely target for treatment of autoimmune diseases.
机构信息
Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, PR China.
Division of Rheumatology, Department of Medicine at Penn State University Hershey College of Medicine, Hershey 17033, USA.
出版信息
Autoimmun Rev. 2014 Jun;13(6):615-20. doi: 10.1016/j.autrev.2013.11.008. Epub 2014 Jan 10.
Abstract
Interleukin-22 (IL-22) is a member of IL-10 family cytokines that is produced by many different types of lymphocytes including both those of the innate and adaptive immune systems. This includes activated T cells, most notably Th17 and Th22 cells, and NK cells, γδ T cells, LTi cells and LTi-like cells. IL-22 mediates its effects via the IL-22-IL-22R complex and subsequent Janus kinase-signal transducer and activators of transcription (JAK-STAT) signaling pathway. Recently accumulated evidence has indicated that IL-22 also plays an important role in the pathogenesis of many autoimmune diseases. In this review, we discuss the recent findings and advancement of the role for IL-22 in several autoimmune diseases, such as psoriasis, rheumatoid arthritis (RA), hepatitis, graft versus host disease (GHVD) and allergic diseases, implicating that target IL-22 may have a therapeutic potential in those autoimmune diseases.
摘要
白细胞介素-22（IL-22）是白细胞介素 10 家族细胞因子的一员，由许多不同类型的淋巴细胞产生，包括先天和适应性免疫系统的细胞。这包括激活的 T 细胞，特别是 Th17 和 Th22 细胞，以及 NK 细胞、γδ T 细胞、LTi 细胞和 LTi 样细胞。IL-22 通过 IL-22-IL-22R 复合物和随后的 Janus 激酶信号转导和转录激活因子（JAK-STAT）信号通路发挥其作用。最近积累的证据表明，IL-22 在许多自身免疫性疾病的发病机制中也起着重要作用。在这篇综述中，我们讨论了 IL-22 在几种自身免疫性疾病中的作用的最新发现和进展，如银屑病、类风湿关节炎（RA）、肝炎、移植物抗宿主病（GHVD）和过敏性疾病，表明靶向 IL-22 可能具有治疗那些自身免疫性疾病的潜力。
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