Hayashi Y, Nagamine S, Yanagawa T, Yoshida H, Yura Y, Azuma M, Sato M
Cancer. 1987 Oct 1;60(7):1583-8. doi: 10.1002/1097-0142(19871001)60:7<1583::aid-cncr2820600728>3.0.co;2-e.
The light microscopic, electron microscopic and immunohistochemical features of a small cell undifferentiated carcinoma of the minor salivary gland are presented. The tumor was composed predominantly of undifferentiated small cells with focally admixed neuroendocrine, exocrine and squamous cells, occasionally arranged in an organoid manner. The presence of vasoactive intestinal polypeptide in the tumor was found immunohistochemically. In addition, the tumor cells stained with Grimelius' impregnation. Immunohistochemically the tumor contained cells that reacted positively with the antibodies to carcinoembryonic antigen, 66K keratin polypeptide, or human salivary amylase. These findings indicate that a small cell undifferentiated carcinoma of the minor salivary gland, reported here, exhibits focally multidirectional differentiation as well as neuroendocrine cell derivation.
本文呈现了小涎腺小细胞未分化癌的光镜、电镜及免疫组化特征。肿瘤主要由未分化的小细胞组成，局部混有神经内分泌细胞、外分泌细胞和鳞状细胞，偶尔呈器官样排列。免疫组化发现肿瘤中存在血管活性肠肽。此外，肿瘤细胞经 Grimelius 染色呈阳性。免疫组化显示肿瘤细胞与癌胚抗原、66K 角蛋白多肽或人唾液淀粉酶抗体呈阳性反应。这些发现表明，本文报道的小涎腺小细胞未分化癌呈现局部多向分化以及神经内分泌细胞起源。
