Ueno Hiroshi, Miyoshi Kenjiro, Fukui Sho, Kondo Yumi, Matsuda Kazuya, Uchide Tsuyoshi
Department of Orthopedic and Neurosurgery, School of Veterinary Medicine, Rakuno Gakuen University, Bunkyo-dai Midori-machi 582 Ebetsu, Hokkaido 069-8501, Japan.
J Vet Med Sci. 2014 May;76(5):723-7. doi: 10.1292/jvms.13-0159. Epub 2014 Jan 13.
An 8-year-old neutered female Cavalier King Charles spaniel was evaluated for progressing right forelimb lameness. Magnetic resonance imaging revealed that the right-side radial nerves and the caudal brachial plexus were swollen. The histological and molecular biological diagnosis by partial biopsy of the C8 spinal nerve was T-cell lymphoma. Coadministration of lomustine and irradiation was started. However, this therapy was ineffective. At necropsy, neoplastic tissues were seen extending into the subarachnoid space of the spinal cord, liver, pancreas and kidneys as gross findings. A large mass was also identified occupying the caudal thorax. Histologic findings included infiltration in these organs and the mass by neoplastic lymphocytes. To date, involvement of peripheral nerves (neurolymphomatosis) is rarely reported in veterinary species.
一只8岁已绝育的雌性骑士查理王小猎犬因右前肢跛行加重前来接受评估。磁共振成像显示右侧桡神经和臂丛后束肿胀。通过对C8脊神经进行部分活检的组织学和分子生物学诊断为T细胞淋巴瘤。开始联合使用洛莫司汀和放疗。然而，这种治疗无效。尸检时，肉眼可见肿瘤组织延伸至脊髓、肝脏、胰腺和肾脏的蛛网膜下腔。还发现一个大肿块占据了胸尾部。组织学检查结果包括肿瘤性淋巴细胞浸润这些器官和肿块。迄今为止，兽医领域很少报道周围神经受累（神经淋巴瘤病）的情况。
