Chamberlain Marc C, Fink James
Department of Neurology and Neurological Surgery, Fred Hutchinson Cancer Research Institute, Seattle Cancer Care Alliance, University of Washington, 825 Eastlake Avenue East, Mailstop: G-4940, P.O. Box 19023, Seattle, WA, 98109-1023, USA.
Department of Radiology, University of Washington, Seattle, WA, USA.
J Neurooncol. 2009 Nov;95(2):285-288. doi: 10.1007/s11060-009-9918-0. Epub 2009 May 16.
To report the occurrence of neurolymphomatosis in a patient with previously treated systemic diffuse B-cell lymphoma (DLBCL). A case report. University medical center. A 54-year old woman with previously treated DLBCL developed sequential mono-, di- and triparesis 3-months after completion of systemic therapy. MR of lumbar and brachial plexus revealed diffuse involvement of nerve roots and plexus. High-dose methotrexate and involved-field radiotherapy. Neurolymphomatosis, although rare, is increasingly recognized with peripheral and central nervous system MRI. Treatment remains unsatisfactory as treatment with methotrexate-based chemotherapy and irradiation is only partially effective.
报告1例既往接受过治疗的系统性弥漫性B细胞淋巴瘤（DLBCL）患者发生神经淋巴瘤病的情况。病例报告。大学医学中心。一名54岁曾接受过DLBCL治疗的女性在全身治疗结束3个月后出现相继的单瘫、双瘫和三肢瘫。腰骶丛和臂丛的磁共振成像显示神经根和神经丛弥漫性受累。给予大剂量甲氨蝶呤和累及野放疗。神经淋巴瘤病虽然罕见，但通过外周和中枢神经系统磁共振成像越来越多地被认识到。由于基于甲氨蝶呤的化疗和放疗仅部分有效，治疗效果仍不尽人意。
