神经淋巴瘤病：弥漫性大B细胞淋巴瘤一种罕见的转移并发症。
Neurolymphomatosis: a rare metastatic complication of diffuse large B-Cell lymphoma.
作者信息
Chamberlain Marc C, Fink James
机构信息
Department of Neurology and Neurological Surgery, Fred Hutchinson Cancer Research Institute, Seattle Cancer Care Alliance, University of Washington, 825 Eastlake Avenue East, Mailstop: G-4940, P.O. Box 19023, Seattle, WA, 98109-1023, USA.
Department of Radiology, University of Washington, Seattle, WA, USA.
出版信息
J Neurooncol. 2009 Nov;95(2):285-288. doi: 10.1007/s11060-009-9918-0. Epub 2009 May 16.
To report the occurrence of neurolymphomatosis in a patient with previously treated systemic diffuse B-cell lymphoma (DLBCL). A case report. University medical center. A 54-year old woman with previously treated DLBCL developed sequential mono-, di- and triparesis 3-months after completion of systemic therapy. MR of lumbar and brachial plexus revealed diffuse involvement of nerve roots and plexus. High-dose methotrexate and involved-field radiotherapy. Neurolymphomatosis, although rare, is increasingly recognized with peripheral and central nervous system MRI. Treatment remains unsatisfactory as treatment with methotrexate-based chemotherapy and irradiation is only partially effective.
报告1例既往接受过治疗的系统性弥漫性B细胞淋巴瘤（DLBCL）患者发生神经淋巴瘤病的情况。病例报告。大学医学中心。一名54岁曾接受过DLBCL治疗的女性在全身治疗结束3个月后出现相继的单瘫、双瘫和三肢瘫。腰骶丛和臂丛的磁共振成像显示神经根和神经丛弥漫性受累。给予大剂量甲氨蝶呤和累及野放疗。神经淋巴瘤病虽然罕见，但通过外周和中枢神经系统磁共振成像越来越多地被认识到。由于基于甲氨蝶呤的化疗和放疗仅部分有效，治疗效果仍不尽人意。
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