原发性胆汁性肝硬化合并干燥综合征的临床特征

[Clinical characteristics of primary biliary cirrhosis complicating Sjögren syndrome].

作者信息

Gao Li-xia, Wang Li, Zhang Feng-chun

机构信息

Department of Rheumatology, Peking Union Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing 100032, China.

Department of Rheumatology, Peking Union Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing 100032, China. Email:

出版信息

Zhonghua Yi Xue Za Zhi. 2013 Nov 19;93(43):3457-9.

PMID:24423911

Abstract

OBJECTIVE

To explore the clinical characteristics of primary biliary cirrhosis (PBC) with Sjögren syndrome (SS) so as to seek diagnostic rationales.

METHODS

Sixty-four PBC patients, 57 SS patients and 93 PBC with SS patients were recruited from Peking Union College Hospital between 2006 and 2009. And their clinical, laboratory and pathological data were analyzed.

RESULTS

The patients of PBC with SS (53 ± 10) years were older than those of PBC (50 ± 11) years (P < 0.05) or SS (48 ± 14) years (P < 0.05) ; Comparing PBC with SS and SS, fever was more in SS (P < 0.05) ;compare with PBC, the positive rates of anti-centromere antibody (ACA) (P < 0.05) and anti-SSA antibody (P < 0.05) increased obviously in PBC with SS. Comparing with SS, the positive rate of anti-SSA antibody (P < 0.05) and anti-SSB antibody (P < 0.05) were apparently increased obviously in PBC with SS.

CONCLUSION

PBC with SS is a special subgroup with the characteristic both PBC and SS. But it can not differentiate from PBC or SS, Anti-SSA antibody and ACA are helpful for diagnosis of PBC with SS.

摘要

目的

探讨原发性胆汁性肝硬化（PBC）合并干燥综合征（SS）的临床特征，以寻求诊断依据。

方法

2006年至2009年从北京协和医院招募了64例PBC患者、57例SS患者和93例PBC合并SS患者。对他们的临床、实验室和病理数据进行分析。

结果

PBC合并SS患者的年龄为（53±10）岁，大于PBC患者（50±11）岁（P<0.05）或SS患者（48±14）岁（P<0.05）；与PBC合并SS和SS相比，SS患者发热更多（P<0.05）；与PBC相比，PBC合并SS患者的抗着丝点抗体（ACA）阳性率（P<0.05）和抗SSA抗体阳性率（P<0.05）明显升高。与SS相比，PBC合并SS患者的抗SSA抗体阳性率（P<0.05）和抗SSB抗体阳性率（P<0.05）明显升高。