Department of Immunology and Infectious Diseases, Johns Hopkins School of Hygiene and Infectious Diseases, Baltimore, MD, USA.
World J Microbiol Biotechnol. 1991 Mar;7(2):105-9. doi: 10.1007/BF00328978.
The ideal vaccine is discussed under three headings. 1. The major requirements of the vaccine. This includes primarlly safety and efficacy and a number of other desirable features if the vaccine is to control a disease of global importance. These include cost, easy administration (e.g. orally), thermal stability, multivalency and long-lived immunlty 2. The nature and persistence of the immune responses which, as judged by model systems, are probably generated by the most effective viral vaccines in current human usage. 3. Approaches for developing future 'simplified" vaccines with similar levels of safety and efficacy so that these objectives are achieved.
理想的疫苗可从以下三个方面来讨论。1. 疫苗的主要要求。这主要包括安全性和有效性，以及如果疫苗要控制具有全球重要性的疾病，则还需要一些其他理想特性。这些特性包括成本、易于管理（例如口服）、热稳定性、多价性和长期免疫性。2. 根据模型系统判断，免疫反应的性质和持久性可能是由当前人类使用的最有效的病毒疫苗产生的。3. 开发未来具有类似安全性和有效性的“简化”疫苗的方法，以实现这些目标。
