Swales J D
J Cardiovasc Pharmacol. 1987;9 Suppl 3:S22-5. doi: 10.1097/00005344-198700003-00006.
The effects of antihypertensive drugs on the quality of life are complex. Drugs may affect the enjoyment of life through central actions but also through a psychological response to pharmacological actions elsewhere in the body. In addition, the patient's expectation of the consequences of disease and its treatment may significantly influence the quality of his or her life. The effect of prior expectations by both the patient and the doctor, the different methods for assessing the quality of life effects, and the high level of individual variability make any assessment of the absolute importance of quality of life adverse effects extremely difficult. However, comparison of ACE inhibitors with more long-standing forms of antihypertensive therapy suggests a rather more favourable impact of ACE inhibition on the quality of life.
抗高血压药物对生活质量的影响是复杂的。药物可能通过中枢作用影响生活乐趣，但也会通过对身体其他部位药理作用的心理反应产生影响。此外，患者对疾病及其治疗后果的预期可能会显著影响其生活质量。患者和医生先前的预期、评估生活质量影响的不同方法以及高度的个体差异，使得对生活质量不良影响的绝对重要性进行任何评估都极为困难。然而，将血管紧张素转换酶抑制剂与更长期的抗高血压治疗形式进行比较表明，血管紧张素转换酶抑制对生活质量的影响更为有利。
