聚乙二醇化纳米脂质体青蒿素对乳腺癌细胞系的毒性作用研究
Study of toxicity effect of pegylated nanoliposomal artemisinin on breast cancer cell line.
作者信息
Dadgar Neda, Alavi Seyed Ebrahim, Esfahani Maedeh Koohi Moftakhari, Akbarzadeh Azim
机构信息
Department of Agricultural Biotechnology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran ; Department of Pilot Biotechnology, Pasteur Institute of Iran, Tehran, Iran.
出版信息
Indian J Clin Biochem. 2013 Oct;28(4):410-2. doi: 10.1007/s12291-013-0306-3. Epub 2013 Feb 10.
Nano carriers have greatly revolutionized the treatment of most diseases recently. One of these nano carriers, liposomes, has got particular significance. On the other hand, Artemisinin which is used as an effective anticancer drug has some side effects. To reduce such side effects, liposomes can be employed. In order to prepare pegylated nanoliposomal artemisinin, particular proportions of phosphatidylcholine, polyethylene glycol 2000 and artemisinin were combined. As a result, the mean diameter of nano liposomes is 455 nm. Besides, the encapsulation efficiency and the drug release from pegylated nanoliposomes for pegylated nanoliposomal artemisinin are respectively 91.62 ± 3.5 and 5.17 %. The results also show that IC50 of the produced formulation is less than that of the standard drug. This study reveals that the amount of artemisinin cytotoxicity compared to standard drug is increased by pegylated nanoliposomal formulation.
纳米载体最近极大地革新了大多数疾病的治疗方法。这些纳米载体之一，脂质体，具有特别重要的意义。另一方面，用作有效抗癌药物的青蒿素存在一些副作用。为了减少此类副作用，可以使用脂质体。为了制备聚乙二醇化纳米脂质体青蒿素，将特定比例的磷脂酰胆碱、聚乙二醇2000和青蒿素混合。结果，纳米脂质体的平均直径为455纳米。此外，聚乙二醇化纳米脂质体青蒿素的包封率和从聚乙二醇化纳米脂质体中的药物释放率分别为91.62±3.5和5.17%。结果还表明，所制备制剂的IC50低于标准药物。这项研究表明，与标准药物相比，聚乙二醇化纳米脂质体制剂增加了青蒿素的细胞毒性。
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