睡眠质量差对肝硬化患者认知功能的影响。
The effects of poor sleep quality on cognitive function of patients with cirrhosis.
机构信息
Division of Gastroenterology and Hepatology, Department of Internal Medicine University of Illinois at Chicago, Chicago, IL.
Division of Biostatistics, Department of Health Sciences Research.
出版信息
J Clin Sleep Med. 2014 Jan 15;10(1):21-6. doi: 10.5664/jcsm.3350.
OBJECTIVES
This study was conducted to assess the ill-defined relationship between sleep quality and multiple, specific domains of cognitive function in patients with cirrhosis.
METHODS
A comprehensive battery of neuropsychological tests (divided into six neurocognitive domains) and a standardized, validated measure of sleep quality (Pittsburgh Sleep Quality Index [PSQI]) were administered to patients with cirrhosis and without evidence of overt hepatic encephalopathy, recruited from liver transplant and advanced liver disease clinics (n = 34). An inflammatory bowel disease (IBD) control group (n = 23) was similarly recruited and evaluated to control for the secondary effect of a chronic illness on cognition. PSQI global and component scores were used to predict cognitive function in each neurocognitive domain, using linear regression.
RESULTS
Global PSQI scores were significantly higher (indicating poorer sleep quality) in the cirrhosis group (median [range] = 10 [1-19]) than in IBD controls = 5 (1-14); p = 0.002). After controlling for age and education, short duration of sleep was associated with impaired memory for patients with cirrhosis; the use of soporific agents was associated with poor visual-perceptual function in patients with IBD.
CONCLUSIONS
Poor sleep was associated with worsening of the already impaired cognitive function of patients with cirrhosis.
目的
本研究旨在评估肝硬化患者睡眠质量与多个特定认知功能领域之间关系不明确的情况。
方法
从肝移植和晚期肝病诊所招募了无明显肝性脑病证据的肝硬化患者（n=34），并对他们进行了一系列神经心理学测试（分为六个认知领域）和睡眠质量的标准化验证评估（匹兹堡睡眠质量指数 [PSQI]）。还招募了同样患有炎症性肠病（IBD）的对照组（n=23）进行评估，以控制慢性疾病对认知的次要影响。使用线性回归，根据 PSQI 总分和各成分分来预测每个认知领域的认知功能。
结果
与 IBD 对照组（中位数[范围] = 5 [1-14]）相比，肝硬化组的 PSQI 总分（表示睡眠质量较差）显著更高（中位数[范围] = 10 [1-19]；p=0.002）。在控制年龄和教育程度后，肝硬化患者的睡眠持续时间较短与记忆受损有关；而 IBD 患者使用催眠药物与视觉感知功能差有关。
结论
较差的睡眠与肝硬化患者本已受损的认知功能恶化有关。
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