Aoshima K
Tohoku J Exp Med. 1987 Jun;152(2):151-72. doi: 10.1620/tjem.152.151.
Urinary beta 2-microglobulin (beta 2-m), alpha 1-microglobulin (alpha 1-m), amino-nitrogen, glucose, calcium, phosphorus, cadmium concentrations, and pH values were analyzed in urine samples from 187 females aged 55-66 years in the Jinzu River basin, which is known to be a cadmium-polluted area, and from 32 controls living in two adjacent reference areas in 1983-1984. Mean urinary beta 2-m, alpha 1-m, amino-nitrogen, glucose, cadmium concentrations and pH values in the inhabitants of the Jinzu River basin were significantly higher than those in the adjacent reference areas. Sixty-four inhabitants in a cadmium-polluted area were found to have renal tubular dysfunction with urinary beta 2-m level exceeding 1 mg/g creatinine and urinary glucose level exceeding 100 mg/g creatinine. The severity of renal tubular dysfunction in several inhabitants were comparable to those of the patients with Itai-itai disease. Mean cadmium concentrations in rice (mean: 0.32-0.57 ppm) which has been daily consumed by the inhabitants of the Jinzu River basin were significantly higher than those in the reference areas (mean: 0.12-0.13 ppm). The close relationship between cadmium exposure and the degree of renal tubular dysfunction was well demonstrated by principal component analysis.
对187名年龄在55 - 66岁之间、来自已知镉污染地区金足河流域的女性以及1983 - 1984年居住在两个相邻对照地区的32名对照者的尿液样本，分析了尿β2-微球蛋白（β2-m）、α1-微球蛋白（α1-m）、氨基氮、葡萄糖、钙、磷、镉浓度及pH值。金足河流域居民的尿β2-m、α1-m、氨基氮、葡萄糖、镉浓度及pH值均值显著高于相邻对照地区。在一个镉污染地区，发现64名居民存在肾小管功能障碍，其尿β2-m水平超过1mg/g肌酐，尿葡萄糖水平超过100mg/g肌酐。部分居民肾小管功能障碍的严重程度与痛痛病患者相当。金足河流域居民日常食用的大米中的镉浓度均值（均值：0.32 - 0.57ppm）显著高于对照地区（均值：0.12 - 0.13ppm）。主成分分析充分证明了镉暴露与肾小管功能障碍程度之间的密切关系。
