Görsdorf S, Appel K E, Obe G, Hildebrandt A G
Toxicol Lett. 1987 Sep;38(1-2):135-43. doi: 10.1016/0378-4274(87)90121-4.
Bleomycin induced DNA single-strand breaks in Chinese hamster V 79 cells which were detected by the alkaline filter elution assay. In the presence of propylgallate, an antioxidant, the amount of DNA single-strand breaks was significantly reduced. The production of DNA strand breaks by methylnitronitrosoguanidine used as a positive control was not influenced by propylgallate. It is suggested that propylgallate inhibits the generation of DNA single-strand breaks by trapping reactive oxygen species produced by the bleomycin-iron(II) complex.
博来霉素可诱导中国仓鼠V 79细胞中的DNA单链断裂，这可通过碱性滤纸洗脱试验检测到。在抗氧化剂棓丙酯存在的情况下，DNA单链断裂的数量显著减少。用作阳性对照的甲基硝基亚硝基胍所导致的DNA链断裂的产生不受棓丙酯的影响。有人提出，棓丙酯通过捕获博来霉素-铁（II）复合物产生的活性氧来抑制DNA单链断裂的产生。
