Ichiba M, Tomokuni K
Toxicol Lett. 1987 Sep;38(1-2):91-6. doi: 10.1016/0378-4274(87)90115-9.
The urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), delta-aminolevulinic acid (ALA) and coproporphyrin (CP) isomers (I and III) was investigated in rats and workers exposed to lead. Urinary excretion of 5-HIAA, which is the major metabolite of serotonin, was not influenced by the lead exposure. However, a significant increase in urinary ALA and CP was found in rats and workers exposed to lead. In particular, the urinary excretion of CP-III was markedly increased compared to that of CP-I in rats and workers exposed to lead.
对暴露于铅的大鼠和工人的5-羟吲哚乙酸（5-HIAA）、δ-氨基乙酰丙酸（ALA）和粪卟啉（CP）异构体（I和III）的尿排泄情况进行了研究。5-HIAA是血清素的主要代谢产物，其尿排泄不受铅暴露的影响。然而，在暴露于铅的大鼠和工人中，尿ALA和CP显著增加。特别是，在暴露于铅的大鼠和工人中，CP-III的尿排泄量与CP-I相比明显增加。
