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限水和水负荷对铅、δ-氨基乙酰丙酸及粪卟啉尿排泄的影响。

The effects of water restriction and water loading on urinary excretion of lead, delta-aminolevulinic acid and coproporphyrin.

作者信息

Araki S

出版信息

Br J Ind Med. 1978 Nov;35(4):312-7. doi: 10.1136/oem.35.4.312.

Abstract

Alterations in daily urinary excretion of lead, delta-aminolevulinic acid (ALA), coproporphyrin, creatinine and total solutes following water restriction and water loading were examined in nine lead workers. Excretion of lead, ALA and total solutes was significantly decreased when urinary volume was reduced, showing that these values are dependent on urinary volume: conversely, excretion of coproporphyrin and creatinine was independent of urinary volume. Excretion of lead and total solutes was also dependent on creatinine excretion. The renal excretory mechanism of lead, ALA and coproporphyrin is discussed in the light of these findings.

摘要

对9名铅作业工人在限水和给水后每日尿中铅、δ-氨基乙酰丙酸(ALA)、粪卟啉、肌酐和总溶质排泄量的变化进行了研究。当尿量减少时,铅、ALA和总溶质的排泄量显著降低,表明这些数值依赖于尿量;相反,粪卟啉和肌酐的排泄与尿量无关。铅和总溶质的排泄也依赖于肌酐排泄。根据这些研究结果,对铅、ALA和粪卟啉的肾排泄机制进行了讨论。

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