铅暴露小鼠和大鼠中δ-氨基乙酰丙酸和粪卟啉尿排泄的种属差异
Species difference of urinary excretion of delta-aminolevulinic acid and coproporphyrin in mice and rats exposed to lead.
作者信息
Tomokuni K, Ichiba M, Hirai Y
机构信息
Department of Community Health Science, Saga Medical School, Japan.
出版信息
Toxicol Lett. 1988 Jun;41(3):255-9. doi: 10.1016/0378-4274(88)90062-8.
The urinary excretion of delta-aminolevulinic acid (ALA) was first investigated in mice exposed to lead in the drinking water (500 ppm) for 30 days, and the results were compared with those obtained from rats exposed to lead under the same exposure condition. The result indicated that the level of urinary ALA excretion in lead-exposed mice was much higher than that in lead-exposed rats. This finding suggests a species difference between mice and rats with regard to sensitivity to lead. On the other hand, urinary coproporphyrin (CP) was also determined in rats and mice exposed to lead. The result obtained indicated that the increasing level of urinary CP excretion was higher in rats than in mice, contrary to expectation. The reason for the discrepancy between urinary excretion of ALA and that of CP in rats and mice exposed to lead is, however, unknown.
首先对饮用含铅（500 ppm）水30天的小鼠的δ-氨基乙酰丙酸（ALA）尿排泄情况进行了研究，并将结果与在相同暴露条件下接触铅的大鼠的结果进行了比较。结果表明，接触铅的小鼠的尿ALA排泄水平远高于接触铅的大鼠。这一发现表明，小鼠和大鼠对铅的敏感性存在物种差异。另一方面，还对接触铅的大鼠和小鼠的尿粪卟啉（CP）进行了测定。得到的结果表明，与预期相反，大鼠尿CP排泄水平的升高高于小鼠。然而，接触铅的大鼠和小鼠中ALA和CP尿排泄之间差异的原因尚不清楚。
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