Brambilla L, Boneschi V, Pigatto P D, Finzi A F, Marinig C, Renoldi P, Fiorini G F
Acta Derm Venereol. 1987;67(3):211-7.
Forty-one patients with primary Kaposi's sarcoma (KS) have been evaluated clinically, histologically and immunologically at the time of diagnosis. There was no correlation between histological and immunological features. Moreover, the disease did not appear to be related to particular HLA phenotypes. The T4/T8 ratio was augmented. Leu 7+ cells were also significantly increased. The last 15 patients who received chemotherapy were recently reevaluated after treatment and an increase in B lymphocytes was observed. We also observed that spindle-shaped cells (SSC), which appear later in the histopathological course of the disease, disappear first during chemotherapy, concomitantly with the increase in B cells. We conclude that the course of the disease appears to be controlled by the host's immune response, though there is no clear correlation between histological and immunological evolution. Several immunological features differentiating it from AIDS associated KS have been found.
41例原发性卡波西肉瘤（KS）患者在诊断时接受了临床、组织学和免疫学评估。组织学和免疫学特征之间没有相关性。此外，该疾病似乎与特定的HLA表型无关。T4/T8比值升高。Leu 7+细胞也显著增加。最近对接受化疗的最后15例患者在治疗后进行了重新评估，观察到B淋巴细胞增加。我们还观察到，在疾病组织病理学过程中较晚出现的梭形细胞（SSC）在化疗期间首先消失，同时B细胞增加。我们得出结论，尽管组织学和免疫学演变之间没有明确的相关性，但疾病进程似乎受宿主免疫反应控制。已经发现了一些将其与艾滋病相关KS区分开来的免疫学特征。
