Friedman-Birnbaum R, Bergman R, Bitterman-Deutsch O, Weltfriend S, Lichtig C
Department of Dermatology, Rambam Medical Center, Haifa, Israel.
Am J Dermatopathol. 1993 Dec;15(6):523-7.
The histological findings in the first diagnostic biopsy of 50 patients with Kaposi's sarcoma (KS) were classified and were related to the clinical course. Forty-one patients had the "classic KS," of whom 31 had a benign course and 10 an aggressive disease. Nine patients had iatrogenically induced KS. Histologically the following subtypes were found: mixed type in 18 patients, spindle type in 16, early type in 14, and hemangiomatous and lymphangiomatous types in one each. We did not find any statistical relationship between the histological subtypes, degree of nuclear atypia, number of mitoses, and density of the inflammatory cell infiltrates in the KS lesions, and the clinical types and course of the disease. The results of this study do not support the possibility of a prognostic importance regarding the histological features of the early lesions in patients with classic or iatrogenic Kaposi's sarcoma.
对50例卡波西肉瘤（KS）患者首次诊断性活检的组织学结果进行了分类，并与临床病程相关联。41例患者为“经典型KS”，其中31例病程良性，10例病情侵袭性。9例患者为医源性诱发的KS。组织学上发现以下亚型：18例为混合型，16例为梭形细胞型，14例为早期型，各有1例为血管瘤型和淋巴管瘤型。我们未发现KS病变的组织学亚型、核异型程度、有丝分裂数以及炎性细胞浸润密度与疾病的临床类型和病程之间存在任何统计学关系。本研究结果不支持经典型或医源性卡波西肉瘤患者早期病变的组织学特征具有预后重要性这一可能性。
