人类白细胞抗原B39与银屑病关节炎的轴向型
HLA-B39 and the axial type of psoriatic arthritis.
作者信息
Crivellato E, Zacchi T
出版信息
Acta Derm Venereol. 1987;67(3):249-50.
PMID:2442939
Abstract
The frequency distribution of HLA-B38 and HLA-B39 was studied in a group of 50 unrelated psoriatic arthritis patients. A high increase of HLA-B39 was noted in the subgroup with axial arthropathy. All B39 positive patients presented with spondylitis and/or sacroiliitis. The hypothesis is formulated that HLA-B39 may discriminate a genetic subset of psoriatic arthritis characterized by a particular susceptibility to develop axial involvement.
摘要
对一组50名无亲缘关系的银屑病关节炎患者进行了HLA - B38和HLA - B39的频率分布研究。在伴有轴性关节病的亚组中，发现HLA - B39显著增加。所有B39阳性患者均出现脊柱炎和/或骶髂关节炎。由此提出假说：HLA - B39可能区分出银屑病关节炎的一个遗传亚组，其特征是特别易发生轴性受累。
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