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棘阿米巴基因型对西班牙棘阿米巴角膜炎患者临床病程及预后的影响。

Influence of Acanthamoeba genotype on clinical course and outcomes for patients with Acanthamoeba keratitis in Spain.

作者信息

Arnalich-Montiel Francisco, Lumbreras-Fernández Blanca, Martín-Navarro Carmen M, Valladares Basilio, Lopez-Velez Rogelio, Morcillo-Laiz Rafael, Lorenzo-Morales Jacob

机构信息

Cornea Unit, Ophthalmology Department, IRYCIS, Ramón y Cajal Hospital, Madrid, Spain.

出版信息

J Clin Microbiol. 2014 Apr;52(4):1213-6. doi: 10.1128/JCM.00031-14. Epub 2014 Jan 15.

DOI:10.1128/JCM.00031-14
PMID:24430449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3993498/
Abstract

Genotype T4 is by far the most frequent genotype of Acanthamoeba keratitis (AK) and therefore has been considered the most virulent. This study included 14 cases of AK of genotype T4 and three cases of non-T4 genotype. We found that cases of non-T4 genotype had a worse response to medical therapy, greater need for surgical intervention, greater risk of extracorneal involvement, and remarkably poorer final visual outcome than those of T4 genotype, suggesting an association between Acanthamoeba virulence and genotype that requires additional case investigation.

摘要

基因型T4是棘阿米巴角膜炎（AK）迄今为止最常见的基因型，因此被认为是毒性最强的。本研究纳入了14例T4基因型的AK病例和3例非T4基因型病例。我们发现，非T4基因型病例对药物治疗的反应较差，更需要手术干预，角膜外受累的风险更大，最终视力结果明显比T4基因型病例差，这表明棘阿米巴的毒力与基因型之间存在关联，需要进一步进行病例调查。

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