与恶性疟原虫疟疾相关的塌陷性肾小球病和溶血尿毒综合征：完全可逆的急性肾损伤
Collapsing glomerulopathy and hemolytic uremic syndrome associated with falciparum malaria: completely reversible acute kidney injury.
作者信息
Kute Vivek Balkrishna, Trivedi Hargovind L, Vanikar Aruna V, Shah Pankaj R, Gumber Manoj R, Kanodia Kamal V
机构信息
Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences [IKDRC-ITS], Civil Hospital Campus, Asarwa, Ahmedabad, 380016 Gujarat India.
Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, IKDRC-ITS, Ahmedabad, India.
出版信息
J Parasit Dis. 2013 Oct;37(2):286-90. doi: 10.1007/s12639-012-0164-6. Epub 2012 Sep 6.
Acute kidney injury (AKI) is one of the most dreaded complications of severe malaria. Herein, we report a case of spontaneous resolution of AKI due to collapsing glomerulopathy (CG) and hemolytic-uremic syndrome (HUS) associated with P. falciparum malaria. Our case report highlights the fact that early intervention on the triggering cause of CG without a long course of steroids may obtain a remission of this severe subset of CG and may obtain a remission of HUS without therapeutic plasmapheresis The etiologic treatment of CG and HUS may avoid progression to end-stage renal disease.
急性肾损伤（AKI）是重症疟疾最可怕的并发症之一。在此，我们报告一例因恶性疟原虫疟疾相关的塌陷性肾小球病（CG）和溶血尿毒综合征（HUS）导致的AKI自发缓解病例。我们的病例报告强调了这样一个事实，即对CG的触发原因进行早期干预而无需长期使用类固醇，可能使这种严重亚型的CG得到缓解，并且在不进行治疗性血浆置换的情况下也可能使HUS得到缓解。CG和HUS的病因治疗可能避免进展至终末期肾病。
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