各种唑类药物对引起外阴阴道念珠菌病的念珠菌属的药敏模式。
Susceptibility pattern of various azoles against Candida species causing vulvovaginal candidiasis.
作者信息
Dharmik Preeti G, Gomashe A V, Upadhyay V G
机构信息
Department of Microbiology, Shri Shivaji Science College, Nagpur, 440012 Maharashtra India.
出版信息
J Obstet Gynaecol India. 2013 Apr;63(2):135-7. doi: 10.1007/s13224-012-0280-3. Epub 2012 Nov 2.
OBJECTIVES
Vulvovaginal candidiasis (VVC) is a common gynecological finding among the women worldwide. Candida species are often less susceptible to antifungal agents. Owing to this fact, in this study, we aimed at assessing the prevalence rate and antimicrobial susceptibility pattern of various azoles against Candida species causing VVC in symptomatic women.
METHODS
The prospective study included 217 female patients with symptoms of vaginal discharges. Specimens were characterized microscopically and were subjected to antimicrobial susceptibility testing against various azoles according to NCCLSM44 disk-diffusion method.
RESULTS
VVC was detected in 18.4 % of the cases. Based on age distribution, the highest rate of Candida infection was observed in the age group of 20-29 years (42.5 %). Antifungal susceptibility revealed that fluconazole was highly effective against Candida Species (97.2 %); on the contrary, the highest resistance was observed in the case of miconazole (63 %).
CONCLUSION
In the current study, prevalence rate of VVC was found to be 18.4 %, and among the various azoles tested, fluconazole has the highest antimicrobial activity.
目的
外阴阴道念珠菌病（VVC）是全球女性中常见的妇科病症。念珠菌属对抗真菌药物往往不太敏感。鉴于此，在本研究中，我们旨在评估有症状女性中引起VVC的各种念珠菌属的患病率以及各种唑类药物的抗菌药敏模式。
方法
这项前瞻性研究纳入了217例有阴道分泌物症状的女性患者。对标本进行显微镜检查，并根据NCCLSM44纸片扩散法对各种唑类药物进行抗菌药敏试验。
结果
18.4%的病例检测出VVC。根据年龄分布，念珠菌感染率最高的是20 - 29岁年龄组（42.5%）。抗菌药敏结果显示，氟康唑对念珠菌属高度有效（97.2%）；相反，咪康唑的耐药率最高（63%）。
结论
在本研究中，VVC的患病率为18.4%，在所测试的各种唑类药物中，氟康唑具有最高的抗菌活性。
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