一名患有矽肺的免疫功能正常男性的脑组织中出现了阿皮尤斯孢子丝菌脑脓肿。
Scedosporium apiospermum brain abscesses in an immunocompetent man with silicosis.
作者信息
Wilson Heather L, Kennedy Karina J
机构信息
Canberra Hospital and Health Services, P.O. Box 11 Woden, ACT 2606, Australia.
Canberra Hospital and Health Services, P.O. Box 11 Woden, ACT 2606, Australia ; Australian National University Medical School, Canberra ACT 0200, Australia.
出版信息
Med Mycol Case Rep. 2013 Mar 1;2:75-8. doi: 10.1016/j.mmcr.2013.02.006.
Abstract
We report a case of Scedosporium apiosporum brain abscesses in an immunocompetent 69-year-old man with a history of silicosis. Delayed diagnosis and institution of antifungal therapy was associated with neurological impairment, with subsequent complications resulting in death, highlighting the need for early diagnostic aspiration of brain abscesses non-responsive to antibiotics. We propose that, in the absence of identifiable immunosuppression, silicosis may have been a contributing factor to the development of central nervous system infection.
摘要
我们报告一例69岁免疫功能正常、有矽肺病史的男性发生的阿皮瘤状瓶霉脑脓肿。抗真菌治疗的延迟诊断和开始与神经功能损害相关，随后的并发症导致死亡，这突出了对对抗生素无反应的脑脓肿进行早期诊断性穿刺抽吸的必要性。我们提出，在没有可识别的免疫抑制情况下，矽肺可能是导致中枢神经系统感染发生的一个促成因素。
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