接受抗逆转录病毒治疗患者的血清脂肪因子与HIV病毒复制

Serum adipokines and HIV viral replication in patients undergoing antiretroviral therapy.

作者信息

Aramă Victoria, Tilişcan Cătălin, Ion Daniela Adriana, Mihăilescu Raluca, Munteanu Daniela, Streinu-Cercel Anca, Tudor Ana Maria, Hristea Adriana, Leoveanu Viorica, Olaru Ioana, Aramă Stefan Sorin

机构信息

MD, PhD, Associate Professor, Department of Infectious Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, National Institute for Infectious Diseases 'Prof. Dr. Matei Balş', Romania.

Assistant Lecturer, Department of Physiopathology and Immunology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

出版信息

Germs. 2012 Mar 1;2(1):12-7. doi: 10.11599/germs.2012.1008.

DOI:10.11599/germs.2012.1008

PMID:24432258

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3882834/

Abstract

INTRODUCTION

Several studies have reported that cytokines secreted by adipose tissue (adipokines) may be linked to HIV replication. The aim of the study was to evaluate the relationship between HIV replication and serum levels of adipokines, in a Caucasian HIV-infected population of men and women undergoing complex antiretroviral therapy.

METHODS

A cross-sectional study was conducted in an unselected sample of 77 HIV-1-positive patients. Serum adipokines levels were measured including circulating adiponectin, leptin, resistin, tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6). Patients were divided into two groups: Group 1 - with undetectable viral load and Group 2 - with persistent HIV viral replication. Differences between groups ? were tested using independent-sample t-test for Gaussian variables and Mann-Whitney-Wilcoxon test for non-parametric variables. Pearson's chi-squared test was used for correlation analysis.

RESULTS

A total of 77 patients (age range: 17-65, mean: 32.5 years) including 44 men (57.1% men, age range: 17-63 years, mean: 34.1 years) and 33 women (42.9% women age range: 19-65 years, mean: 30.3 years) were included in the study. TNF-alpha had significantly higher serum levels in patients with detectable viral load (16.89 vs. 9.35 pg/mL), (p=0.043), but correlation analysis lacked statistical significance. Adiponectin had median serum levels of 9.22 ìg/mL in Group 1 vs. 16.50 ìg/mL in Group 2 but the results lacked statistical significance (p=0.059). Higher leptin, IL-6 and resistin serum levels were noted in patients with undetectable HIV viral load, without statistical significance.

CONCLUSIONS

The present study reported higher TNF-alpha serum levels in patients with persistent HIV viral load. We found no statistically significant correlations between adiponectin, leptin, resistin and IL-6 and HIV viral load in our Caucasian HIV-positive study population, undergoing antiretroviral therapy.

摘要

引言

多项研究报告称，脂肪组织分泌的细胞因子（脂肪因子）可能与HIV复制有关。本研究的目的是评估在接受复杂抗逆转录病毒治疗的白种人HIV感染人群中，HIV复制与血清脂肪因子水平之间的关系。

方法

对77例HIV-1阳性患者的未选择样本进行了横断面研究。测量血清脂肪因子水平，包括循环脂联素、瘦素、抵抗素、肿瘤坏死因子α（TNF-α）和白细胞介素-6（IL-6）。患者分为两组：第1组——病毒载量不可检测；第2组——存在持续性HIV病毒复制。组间差异对高斯变量使用独立样本t检验，对非参数变量使用曼-惠特尼-威尔科克森检验。采用Pearson卡方检验进行相关性分析。

结果

本研究共纳入77例患者（年龄范围：17 - 65岁，平均：32.5岁），其中男性44例（占57.1%，年龄范围：17 - 63岁，平均：34.1岁），女性33例（占42.9%，年龄范围：19 - 65岁，平均：30.3岁）。病毒载量可检测的患者中TNF-α血清水平显著更高（16.89对9.35 pg/mL），（p = 0.043），但相关性分析缺乏统计学意义。第1组脂联素血清中位数水平为9.22μg/mL，第2组为16.50μg/mL，但结果缺乏统计学意义（p = 0.059）。HIV病毒载量不可检测的患者中瘦素、IL-6和抵抗素血清水平较高，但无统计学意义。