Söderström K O
Department of Pathology, University of Turku, Finland.
Cancer. 1987 Oct 15;60(8):1823-31. doi: 10.1002/1097-0142(19871015)60:8<1823::aid-cncr2820600825>3.0.co;2-3.
The binding of different lectins (concanavalin A [Con A], triticum vulgaris [WGA], glycine maximum [SBA], dolichos bilflorus [DBA], ulex europaeus [UEA I], arachis hypogaea [PNA], and ricinus communis [RCA I]) to cells of normal prostate glands, hyperplastic glands and adenocarcinoma was studied. The Con A, WGA, DBA, PNA and RCA I bound to both normal and hyperplastic glands. The binding in the malignant glands differed from that of the benign conditions. The SBA, which was not bound by benign cells, was bound to the malignant glandular cells. Also, UEA I was bound to a part of the carcinoma cells. In addition, the binding pattern of Con A and WGA in the cells differed between the malignant and benign conditions. Based on the results of this study, it is suggested that lectin histochemical study might be useful in routine pathologic examination to detect malignant cells in cases which are doubtful with regard to malignancy by routine methods.
研究了不同凝集素（伴刀豆球蛋白A [Con A]、小麦胚凝集素[WGA]、大豆凝集素[SBA]、双花扁豆凝集素[DBA]、荆豆凝集素[UEA I]、花生凝集素[PNA]和蓖麻凝集素[RCA I]）与正常前列腺腺细胞、增生性腺细胞及腺癌细胞的结合情况。Con A、WGA、DBA、PNA和RCA I与正常及增生性腺细胞均有结合。恶性腺细胞中的结合情况与良性情况不同。未被良性细胞结合的SBA与恶性腺癌细胞结合。此外，UEA I与部分癌细胞结合。另外，Con A和WGA在细胞中的结合模式在恶性和良性情况下也有所不同。基于本研究结果，提示凝集素组织化学研究在常规病理检查中可能有助于检测常规方法对恶性程度存疑病例中的恶性细胞。
