Suppr超能文献

[Effect of the tumor-bearing host serum on the leukocyte adherence inhibition reaction mediated by immune RNA].

作者信息

Wang X M, Wang C J, Su C Z

机构信息

Fourth Military Medical College, PLA, Xi'an.

出版信息

Zhonghua Zhong Liu Za Zhi. 1987 Mar;9(2):106-8.

PMID:2443326
Abstract

51Cr-labelled leucocyte adherence inhibition (LAI) assay was used as an index to study the activity of xenogenic immune RNA (iRNA) in inducing normal LACA mouse spleen lymphocytes to mediate tumor specific response in vitro. RNA was extracted from the spleen and lymph nodes of the guinea pigs immunized by S180 or H22 ascitic tumor cells and from those of the normal guinea pigs. Extracts of S180 or H22 tumor cells and that of normal LACA mouse livers were prepared by PBS method respectively. Three kinds of RNA and three kinds of cell (tissue) extracts were grouped into nine combinations. A defined number of 51Cr-labelled lymphocytes was added to each group. The results showed that only in the combination of two kinds of iRNA and the corresponding tumor cell extract, adherence of normal lymphocyte was significantly inhibited. Serum from tumor bearing host inhibited LAI reaction mediated by iRNA. The "blocking" effect was specific since it occurred only when the serum and tumor extract in the reaction system were taken from the same tumor-bearing donor.

摘要

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验