Belokhvostov A S, Ogurtsov R P, Grishchenko Iu D, Zelenkova N K, Zubzhitskiĭ Iu N
Vopr Onkol. 1979;25(7):68-70.
Under study was the influence of the nucleic factor, isolated from Ehrlich tumor ascitic fluid, on cytotoxicity of in vitro lymphocytes of CC57Br mice immunized by L-cells. In a dose of 5--10 mkm/ml this factor was shown to suppress cytotoxicity of splenic cells as well as that of lymph nodes cells of previously immunized mice. Cellular DNA of non-lineal SHR mice, hepatic RNA of normal mice C3Ha (their genotype being similar to L-cells), of non-lineal SHR mice and syngeneic CC75Br in the same concentration failed to produce such effect.
研究了从艾氏腹水瘤液中分离出的核酸因子对经L细胞免疫的CC57Br小鼠体外淋巴细胞细胞毒性的影响。结果显示，该因子在5 - 10微克/毫升的剂量下，能抑制先前免疫小鼠的脾细胞和淋巴结细胞的细胞毒性。相同浓度的非近交系SHR小鼠的细胞DNA、正常C3Ha小鼠（其基因型与L细胞相似）的肝RNA、非近交系SHR小鼠以及同基因CC75Br小鼠的肝RNA均未产生这种作用。
